Abstract
Aims: Despite the emergence of sorafenib as the standard treatment for patients with advanced hepatocellular cancer (HCC), therapy remains sub-optimal and toxic. Methods: We report on five patients with advanced HCC treated with bevacizumab, oxaliplatin and doxorubicin or liposomal doxorubicin. Results: Of the five patients, four had cirrhosis; two patients had Child-Pugh A cirrhosis, while one each had Child-Pugh B and C cirrhosis. Grade 3/4 toxicity was uncommon. Four patients had a decrease of ≥50% in alpha-fetoprotein levels following therapy and one patient each had a radiographic complete response and stable disease. Conclusion: These data add to the growing phase II data that bevacizumab-containing regimens are active in advanced HCC patients. Further evaluation of regimens containing bevacizumab with oxaliplatin and/or doxorubicin may be warranted.
Original language | English (US) |
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Pages (from-to) | 174-179 |
Number of pages | 6 |
Journal | Asia-Pacific Journal of Clinical Oncology |
Volume | 7 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2011 |
Keywords
- Bevacizumab
- Chemotherapy
- Doxorubicin
- Hepatocellular carcinoma
- Oxaliplatin
ASJC Scopus subject areas
- Oncology