Bevacizumab in combination with oxaliplatin and doxorubicin or liposomal doxorubicin for hepatocellular cancer: A case series

Geoffrey Y. Ku, Gilberto De Lima Lopes, Alex Y. Chang

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Despite the emergence of sorafenib as the standard treatment for patients with advanced hepatocellular cancer (HCC), therapy remains sub-optimal and toxic. Methods: We report on five patients with advanced HCC treated with bevacizumab, oxaliplatin and doxorubicin or liposomal doxorubicin. Results: Of the five patients, four had cirrhosis; two patients had Child-Pugh A cirrhosis, while one each had Child-Pugh B and C cirrhosis. Grade 3/4 toxicity was uncommon. Four patients had a decrease of ≥50% in alpha-fetoprotein levels following therapy and one patient each had a radiographic complete response and stable disease. Conclusion: These data add to the growing phase II data that bevacizumab-containing regimens are active in advanced HCC patients. Further evaluation of regimens containing bevacizumab with oxaliplatin and/or doxorubicin may be warranted.

Original languageEnglish (US)
Pages (from-to)174-179
Number of pages6
JournalAsia-Pacific Journal of Clinical Oncology
Volume7
Issue number2
DOIs
StatePublished - Jun 1 2011

Keywords

  • Bevacizumab
  • Chemotherapy
  • Doxorubicin
  • Hepatocellular carcinoma
  • Oxaliplatin

ASJC Scopus subject areas

  • Oncology

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