Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study

Majid Fotuhi, Peter P. Zandi, Kathleen M. Hayden, Ara S. Khachaturian, Christine A. Szekely, Heidi Wengreen, Ronald G. Munger, Maria C. Norton, Jo Ann T. Tschanz, Constantine G. Lyketsos, John C.S. Breitner, Kathleen Welsh-Bohmer

Research output: Contribution to journalArticle

Abstract

Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P < .05). This apparent effect was attributable entirely to participants with the APOE ε4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P < .05). These results suggest that among elderly individuals with an APOE ε4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.

Original languageEnglish (US)
Pages (from-to)223-227
Number of pages5
JournalAlzheimer's and Dementia
Volume4
Issue number3
DOIs
StatePublished - May 1 2008

Keywords

  • Antioxidant vitamins
  • Cognitive performance
  • Dementia prevention
  • NSAIDs
  • Random effect model

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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