Beta-aminoaciduria in patients with burkitt’s lymphomal

T. Phillip Waalkes; Charles W. Gehrke; Duane B. Lakings; Robert W. Zumwalt; Kenneth C. Kuo; Samuel A. Jacobs; Ernest Borek

doi:10.1093/jnci/57.2.435

Beta-aminoaciduria in patients with burkitt’s lymphomal

T. Phillip Waalkes, Charles W. Gehrke, Duane B. Lakings, Robert W. Zumwalt, Kenneth C. Kuo, Samuel A. Jacobs, Ernest Borek

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The massive amounts of β-aminoisobutyric acid (β-AIBA) in the urine of Burkitt’s lymphoma patients were measured along with other α-amino acids and β-alanine present in normal and decreased levels. The ratios of the amount of β-AIBA to β-alanine, in µmoles/kg urine collected in 24 hours, were elevated for all patients. The degree of elevation of β-AIBA excretion and the ratio of the two p-amino acids appeared to be related to the amount of tumor mass present. These analyses may have possible value in monitoring patients with Burkitt’s lymphoma during their disease course.

Original language	English (US)
Pages (from-to)	435-438
Number of pages	4
Journal	Journal of the National Cancer Institute
Volume	57
Issue number	2
DOIs	https://doi.org/10.1093/jnci/57.2.435
State	Published - 1976

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Beta-aminoaciduria in patients with burkitt{\textquoteright}s lymphomal",

abstract = "The massive amounts of β-aminoisobutyric acid (β-AIBA) in the urine of Burkitt{\textquoteright}s lymphoma patients were measured along with other α-amino acids and β-alanine present in normal and decreased levels. The ratios of the amount of β-AIBA to β-alanine, in µmoles/kg urine collected in 24 hours, were elevated for all patients. The degree of elevation of β-AIBA excretion and the ratio of the two p-amino acids appeared to be related to the amount of tumor mass present. These analyses may have possible value in monitoring patients with Burkitt{\textquoteright}s lymphoma during their disease course.",

author = "Waalkes, {T. Phillip} and Gehrke, {Charles W.} and Lakings, {Duane B.} and Zumwalt, {Robert W.} and Kuo, {Kenneth C.} and Jacobs, {Samuel A.} and Ernest Borek",

year = "1976",

doi = "10.1093/jnci/57.2.435",

language = "English (US)",

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T1 - Beta-aminoaciduria in patients with burkitt’s lymphomal

AU - Waalkes, T. Phillip

AU - Gehrke, Charles W.

AU - Lakings, Duane B.

AU - Zumwalt, Robert W.

AU - Kuo, Kenneth C.

AU - Jacobs, Samuel A.

AU - Borek, Ernest

PY - 1976

Y1 - 1976

N2 - The massive amounts of β-aminoisobutyric acid (β-AIBA) in the urine of Burkitt’s lymphoma patients were measured along with other α-amino acids and β-alanine present in normal and decreased levels. The ratios of the amount of β-AIBA to β-alanine, in µmoles/kg urine collected in 24 hours, were elevated for all patients. The degree of elevation of β-AIBA excretion and the ratio of the two p-amino acids appeared to be related to the amount of tumor mass present. These analyses may have possible value in monitoring patients with Burkitt’s lymphoma during their disease course.

AB - The massive amounts of β-aminoisobutyric acid (β-AIBA) in the urine of Burkitt’s lymphoma patients were measured along with other α-amino acids and β-alanine present in normal and decreased levels. The ratios of the amount of β-AIBA to β-alanine, in µmoles/kg urine collected in 24 hours, were elevated for all patients. The degree of elevation of β-AIBA excretion and the ratio of the two p-amino acids appeared to be related to the amount of tumor mass present. These analyses may have possible value in monitoring patients with Burkitt’s lymphoma during their disease course.

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Beta-aminoaciduria in patients with burkitt’s lymphomal

Abstract

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