Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats

Samra Bashir; Anwar H. Gilani; Anwar A. Siddiqui; Shahid Pervez; Saeed R. Khan; Noor Jehan Sarfaraz; Abdul Jabbar Shah

doi:10.1002/ptr.3196

Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats

Samra Bashir, Anwar H. Gilani, Anwar A. Siddiqui, Shahid Pervez, Saeed R. Khan, Noor Jehan Sarfaraz, Abdul Jabbar Shah

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Berberis vulgaris is a widely used plant for the treatment of urolithiasis. To evaluate its antiurolithic potential, the crude aqueous-methanol extract of Berberis vulgaris root bark (Bv.Cr) was tested in an animal model of urolithiasis, developed in male Wistar rats by adding 0.75% ethylene glycol in drinking water. Bv.Cr (50 mg/ kg) inhibited CaOx crystal deposition in renal tubules and protected against associated changes including polyuria, weight loss, impaired renal function and the development of oxidative stress in kidneys. Activity-guided fractionation revealed the concentration of antiurolithic constituent(s) mainly in the aqueous fraction. These data, indicating the presence of antiurolithic activity in Berberis vulgaris root bark, rationalize its medicinal use for the treatment of urolithiasis.

Original language	English (US)
Pages (from-to)	1250-1255
Number of pages	6
Journal	Phytotherapy Research
Volume	24
Issue number	8
DOIs	https://doi.org/10.1002/ptr.3196
State	Published - 2010
Externally published	Yes

Keywords

Animal model
Berberis vulgaris
Calcium oxalate
Urolithiasis

ASJC Scopus subject areas

Pharmacology
General Medicine

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10.1002/ptr.3196

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title = "Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats",

abstract = "Berberis vulgaris is a widely used plant for the treatment of urolithiasis. To evaluate its antiurolithic potential, the crude aqueous-methanol extract of Berberis vulgaris root bark (Bv.Cr) was tested in an animal model of urolithiasis, developed in male Wistar rats by adding 0.75% ethylene glycol in drinking water. Bv.Cr (50 mg/ kg) inhibited CaOx crystal deposition in renal tubules and protected against associated changes including polyuria, weight loss, impaired renal function and the development of oxidative stress in kidneys. Activity-guided fractionation revealed the concentration of antiurolithic constituent(s) mainly in the aqueous fraction. These data, indicating the presence of antiurolithic activity in Berberis vulgaris root bark, rationalize its medicinal use for the treatment of urolithiasis.",

keywords = "Animal model, Berberis vulgaris, Calcium oxalate, Urolithiasis",

author = "Samra Bashir and Gilani, {Anwar H.} and Siddiqui, {Anwar A.} and Shahid Pervez and Khan, {Saeed R.} and Sarfaraz, {Noor Jehan} and Shah, {Abdul Jabbar}",

year = "2010",

doi = "10.1002/ptr.3196",

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AU - Bashir, Samra

AU - Gilani, Anwar H.

AU - Siddiqui, Anwar A.

AU - Pervez, Shahid

AU - Khan, Saeed R.

AU - Sarfaraz, Noor Jehan

AU - Shah, Abdul Jabbar

PY - 2010

Y1 - 2010

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KW - Animal model

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KW - Calcium oxalate

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Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats

Abstract

Keywords

ASJC Scopus subject areas

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