Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats

Samra Bashir, Anwar H. Gilani, Anwar A. Siddiqui, Shahid Pervez, Saeed R. Khan, Noor Jehan Sarfaraz, Abdul Jabbar Shah

Research output: Contribution to journalArticlepeer-review

Abstract

Berberis vulgaris is a widely used plant for the treatment of urolithiasis. To evaluate its antiurolithic potential, the crude aqueous-methanol extract of Berberis vulgaris root bark (Bv.Cr) was tested in an animal model of urolithiasis, developed in male Wistar rats by adding 0.75% ethylene glycol in drinking water. Bv.Cr (50 mg/ kg) inhibited CaOx crystal deposition in renal tubules and protected against associated changes including polyuria, weight loss, impaired renal function and the development of oxidative stress in kidneys. Activity-guided fractionation revealed the concentration of antiurolithic constituent(s) mainly in the aqueous fraction. These data, indicating the presence of antiurolithic activity in Berberis vulgaris root bark, rationalize its medicinal use for the treatment of urolithiasis.

Original languageEnglish (US)
Pages (from-to)1250-1255
Number of pages6
JournalPhytotherapy Research
Volume24
Issue number8
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Animal model
  • Berberis vulgaris
  • Calcium oxalate
  • Urolithiasis

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

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