Abstract
A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to 1 (NSC-639829), against cancer cell lines. 6n was more effective than 1 in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6n retained significant ability to inhibit tubulin assembly, with an IC 50 of 2.1 μM.
Original language | English (US) |
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Pages (from-to) | 2357-2360 |
Number of pages | 4 |
Journal | Journal of medicinal chemistry |
Volume | 49 |
Issue number | 7 |
DOIs | |
State | Published - Apr 6 2006 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery