Benzodiazepines

Jean Luc Fouilladieu, Jerome D'Enfert, Christian Conseiller, Robert Hausner, Theodore Pearlman, David Haskell, Eve Bargmann, Sidney M. Wolfe, David J. Greenblatt, Richard I. Shader

Research output: Contribution to journalLetter

Abstract

To the Editor: We were surprised to note that paradoxical effects of benzodiazepines are not mentioned by Greenblatt and colleagues (Aug. 11 and 18 issues).1 These adverse reactions, including hyperactivity and irritability, were first described, for chlordiazepoxide, by Ingram and Timbury.2 Since then, other paradoxical reactions, such as paradoxical excitement,3 hostile behavior,4 verbal and physical aggression,5 symptoms of delirium,6 rage reaction,7 increased anxiety or panic,8 and increased seizure frequency,3 have been reported. Several benzodiazepines, including chlordiazepoxide,2 diazepam,3,6 clonazepam,3 triazolam,5 lorazepam,6 clorazepate,7 temazepam,8 and clobazam9 have been associated with such reactions. Unlike common side effects (drowsiness and ataxia), which are related.

Original languageEnglish (US)
Pages (from-to)464-466
Number of pages3
JournalNew England Journal of Medicine
Volume310
Issue number7
DOIs
StatePublished - Feb 16 1984
Externally publishedYes

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Chlordiazepoxide
Benzodiazepines
Verbal Behavior
Triazolam
Rage
Clonazepam
Lorazepam
Panic
Temazepam
Delirium
Sleep Stages
Ataxia
Diazepam
Aggression
Seizures
Anxiety

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fouilladieu, J. L., D'Enfert, J., Conseiller, C., Hausner, R., Pearlman, T., Haskell, D., ... Shader, R. I. (1984). Benzodiazepines. New England Journal of Medicine, 310(7), 464-466. https://doi.org/10.1056/NEJM198402163100716

Benzodiazepines. / Fouilladieu, Jean Luc; D'Enfert, Jerome; Conseiller, Christian; Hausner, Robert; Pearlman, Theodore; Haskell, David; Bargmann, Eve; Wolfe, Sidney M.; Greenblatt, David J.; Shader, Richard I.

In: New England Journal of Medicine, Vol. 310, No. 7, 16.02.1984, p. 464-466.

Research output: Contribution to journalLetter

Fouilladieu, JL, D'Enfert, J, Conseiller, C, Hausner, R, Pearlman, T, Haskell, D, Bargmann, E, Wolfe, SM, Greenblatt, DJ & Shader, RI 1984, 'Benzodiazepines', New England Journal of Medicine, vol. 310, no. 7, pp. 464-466. https://doi.org/10.1056/NEJM198402163100716
Fouilladieu JL, D'Enfert J, Conseiller C, Hausner R, Pearlman T, Haskell D et al. Benzodiazepines. New England Journal of Medicine. 1984 Feb 16;310(7):464-466. https://doi.org/10.1056/NEJM198402163100716
Fouilladieu, Jean Luc ; D'Enfert, Jerome ; Conseiller, Christian ; Hausner, Robert ; Pearlman, Theodore ; Haskell, David ; Bargmann, Eve ; Wolfe, Sidney M. ; Greenblatt, David J. ; Shader, Richard I. / Benzodiazepines. In: New England Journal of Medicine. 1984 ; Vol. 310, No. 7. pp. 464-466.
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