Benzodiazepine recognition sites on GABA receptors

Moshe Gavish, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

A role of γ-amino butyric acid (GABA) in benzodiazepine actions1-3 is supported by the GABA stimulation of membrane-bound4-8 and soluble9,10 benzodiazepine receptors and preliminary evidence that GABA protects benzodiazepine receptors from heat inactivation11. We show here that the GABA receptors labelled by 3H-muscimol possess a benzodiazepine recognition site, as benzodiazepines, in proportion to their pharmacological activity, protect 3H-muscimol binding from inactivation by heat and the protein modifying reagent iodoacetamide. We also show that benzodiazepines and GABA act at apparently distinct sites to protect benzodiazepine receptors from heat and iodoacetamide.

Original languageEnglish (US)
Pages (from-to)651-652
Number of pages2
JournalNature
Volume287
Issue number5783
DOIs
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • General

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