Benzodiazepine effects on heart rate conditioning in the rabbit

J. P. Pascoe, M. Gallagher, B. S. Kapp

Research output: Contribution to journalArticlepeer-review

Abstract

The present experiment was undertaken to assess the ways in which benzodiazepine administration alters heart rate responding during Pavlovian aversive conditioning in the rabbit. Each of three benzodiazepine compounds (chlordiazepoxide, flurazepam, diazepam) reliably attenuated the magnitude of the conditioned bradycardia response as compared to vehicle controls. Lower doses of two of these compounds significantly potentiated the conditioned bradycardia response. Benzodiazepine treatment did not singificantly alter baseline heart rate, the expression and habituation of the heart rate orienting response, or heart rate responding during unpaired stimulus presentations. The effects of benzodiazepines under these conditions therefore appeared to be selective to those heart rate responses that were conditioned. These results are consistent with evidence suggesting the involvement of benzodiazepine-sensitive processes in the expression of emotional responses, including concomitant cardiovascular alterations.

Original languageEnglish (US)
Pages (from-to)256-261
Number of pages6
JournalPsychopharmacology
Volume79
Issue number2-3
DOIs
StatePublished - Feb 1 1983
Externally publishedYes

Keywords

  • Anxiety
  • Benzodiazepines
  • Heart rate conditioning
  • Rabbits

ASJC Scopus subject areas

  • Pharmacology

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