Benzo[a]pyrene diol-epoxide (B[a]PDE) upregulates COX-2 expression through MAPKs/AP-1 and IKKβ/NF-κB in mouse epidermal Cl41 cells

Medicine & Life Sciences

• Neurofibromin 1 100%
• Epoxy Compounds 87%
• Benzo(a)pyrene 80%
• Epidermal Cells 75%
• Cyclooxygenase 2 68%
• Up-Regulation 46%
• NFATC Transcription Factors 15%
• Signal Transduction 9%
• 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 8%
• pyrene 8%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 6%
• Proteins 6%
• MAP Kinase Signaling System 6%
• Tacrolimus 6%
• Skin Neoplasms 6%
• Mitogen-Activated Protein Kinases 5%
• Carcinogens 5%
• Phosphotransferases 4%
• Carcinogenesis 4%
• Gene Expression 3%
• Animals 2%
• Neoplasms 1%