Benign soft tissue lesions that may mimic malignancy

Jessica A. Forcucci, Evelyn T. Bruner, Michael Timothy Smith

Research output: Contribution to journalArticlepeer-review


Soft tissue lesions which mimic malignancy (pseudosarcomas), represent a significant diagnostic challenge for pathologists. Many features often associated with malignancy including rapid and infiltrative growth, increased cellularity and mitotic activity, and nuclear pleomorphism are present in benign and reactive conditions. This review highlights repair reactions including nodular fasciitis, proliferative fasciitis/myositis, intravascular papillary endothelial hyperplasia, and fat necrosis; lipoma and spindle cell/pleomorphic lipoma; fibroepithelial stromal (pseudosarcomatoid) polyp; phosphaturic mesenchymal tumor and myxoma. While not inclusive of every pseudoneoplastic soft tissue lesion, this review emphasizes important diagnostic pitfalls and stresses the value of clinical, pathologic, and radiologic correlation.

Original languageEnglish (US)
Pages (from-to)50-59
Number of pages10
JournalSeminars in Diagnostic Pathology
Issue number1
StatePublished - Jan 1 2016


  • Malignancy mimic
  • Pseudoneoplastic
  • Pseudosarcoma
  • Soft tissue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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