TY - JOUR
T1 - Benefits of continuous isoniazid preventive therapy may outweigh resistance risks in a declining TB/HIV co-epidemic
AU - Kunkel, Amber
AU - Crawford, Forrest W.
AU - Shepherd, James
AU - Cohen, Ted
PY - 2016/8/17
Y1 - 2016/8/17
N2 - OBJECTIVE:: Extending the duration of isoniazid preventive therapy (IPT) among people living with HIV (PLHIV) may improve its effectiveness at both the individual and population level, but could also increase selective pressure in favor of isoniazid resistant tuberculosis (TB) strains. The objective of this study was to determine the relative importance of these two effects. METHODS:: Transmission dynamic model DESIGN:: We created a mathematical model of TB transmission incorporating HIV incidence and treatment, mixed strain latent TB infections, and four different phenotypes of TB drug resistance (pan-susceptible, isoniazid mono-resistant, rifampicin mono-resistant, and multi-drug resistant). We used this model to project the effects of IPT duration on the incidence of isoniazid-sensitive and -resistant TB as well as mortality among PLHIV. We evaluated the sensitivity of our baseline model, which was calibrated to data from Botswana, to different assumptions about the future trajectory of the TB epidemic. RESULTS:: Our model suggests that, in the context of a declining TB epidemic such as that currently observed in Botswana, the incidence and mortality benefits of continuous IPT for PLHIV are likely to outweigh the potential resistance risks associated with long duration IPT. However, should TB epidemics fail to remain in control, as was observed during the initial emergence of HIV, the selective pressure imposed by widespread use of continuous IPT on isoniazid resistant TB incidence may erode its initial benefits. CONCLUSIONS:: Resistance concerns are likely insufficient to rule out use of continuous IPT when coupled with effective TB treatment, case finding, and HIV control.
AB - OBJECTIVE:: Extending the duration of isoniazid preventive therapy (IPT) among people living with HIV (PLHIV) may improve its effectiveness at both the individual and population level, but could also increase selective pressure in favor of isoniazid resistant tuberculosis (TB) strains. The objective of this study was to determine the relative importance of these two effects. METHODS:: Transmission dynamic model DESIGN:: We created a mathematical model of TB transmission incorporating HIV incidence and treatment, mixed strain latent TB infections, and four different phenotypes of TB drug resistance (pan-susceptible, isoniazid mono-resistant, rifampicin mono-resistant, and multi-drug resistant). We used this model to project the effects of IPT duration on the incidence of isoniazid-sensitive and -resistant TB as well as mortality among PLHIV. We evaluated the sensitivity of our baseline model, which was calibrated to data from Botswana, to different assumptions about the future trajectory of the TB epidemic. RESULTS:: Our model suggests that, in the context of a declining TB epidemic such as that currently observed in Botswana, the incidence and mortality benefits of continuous IPT for PLHIV are likely to outweigh the potential resistance risks associated with long duration IPT. However, should TB epidemics fail to remain in control, as was observed during the initial emergence of HIV, the selective pressure imposed by widespread use of continuous IPT on isoniazid resistant TB incidence may erode its initial benefits. CONCLUSIONS:: Resistance concerns are likely insufficient to rule out use of continuous IPT when coupled with effective TB treatment, case finding, and HIV control.
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U2 - 10.1097/QAD.0000000000001235
DO - 10.1097/QAD.0000000000001235
M3 - Article
C2 - 27782966
AN - SCOPUS:84983072046
SN - 0269-9370
JO - AIDS
JF - AIDS
ER -