Benefit of intravenous IgG replacement in hypogammaglobulinemic patients with chronic sinopulmonary disease

Chaim M. Roifman, Howard M. Lederman, Sasson Lavi, Leonard D. Stein, Henry Levison, Erwin W. Gelfand

Research output: Contribution to journalArticlepeer-review

Abstract

Seven patients with hypogammaglobulinemia and chronic sinopulmonary infections were treated with a preparation of intravenous gammaglobulin. In order to maintain levels of serum IgG at greater than 500 to 750 mg/dl four weeks after infusion, 0.6 g/kg was administered every month. Stable serum levels were achieved after three to eight months. After six to 12 months of this regimen, there was significant reduction in acute infections requiring hospitalization, amelioration of clinical and radiographic evidence of chronic maxillary sinusitis, and improvement in pulmonary symptoms and pulmonary function test results. The administration of increased amounts of IgG intravenously is of benefit in patients with chronic sinopulmonary infections.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalThe American journal of medicine
Volume79
Issue number2
DOIs
StatePublished - Aug 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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