Beneficial impact of genome projects on tuberculosis control

Gurvaneet S. Randhawa, William Ramses Bishai

Research output: Contribution to journalArticle

Abstract

The M. tuberculosis genome project is a landmark achievement in the history of TB research. The DNA sequence has provided valuable insights, along with a few surprises, into the complete genetic complement of M. tuberculosis. This information has been used to gain a better understanding of isoniazid-induced alteration in gene expression. It also has been used to construct a genealogy tree of different BCG strains, besides identifying genes that may be responsible for the human-specificity of M. tuberculosis. The impact of this project is far-reaching and in the next few years should yield innovative vaccines and therapeutic agents, besides aiding in the rapid and accurate diagnosis of TB.

Original languageEnglish (US)
Pages (from-to)145-161
Number of pages17
JournalInfectious Disease Clinics of North America
Volume16
Issue number1
DOIs
StatePublished - 2002

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Tuberculosis
Genome
Genealogy and Heraldry
Isoniazid
Mycobacterium bovis
Vaccines
History
Gene Expression
Research
Genes
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Beneficial impact of genome projects on tuberculosis control. / Randhawa, Gurvaneet S.; Bishai, William Ramses.

In: Infectious Disease Clinics of North America, Vol. 16, No. 1, 2002, p. 145-161.

Research output: Contribution to journalArticle

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