Beneficial impact of genome projects on tuberculosis control

Gurvaneet S. Randhawa, William R. Bishai

Research output: Contribution to journalReview article

Abstract

The M. tuberculosis genome project is a landmark achievement in the history of TB research. The DNA sequence has provided valuable insights, along with a few surprises, into the complete genetic complement of M. tuberculosis. This information has been used to gain a better understanding of isoniazid-induced alteration in gene expression. It also has been used to construct a genealogy tree of different BCG strains, besides identifying genes that may be responsible for the human-specificity of M. tuberculosis. The impact of this project is far-reaching and in the next few years should yield innovative vaccines and therapeutic agents, besides aiding in the rapid and accurate diagnosis of TB.

Original languageEnglish (US)
Pages (from-to)145-161
Number of pages17
JournalInfectious disease clinics of North America
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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