Beneficial effects of histocompatibility in high-risk corneal transplantation

Gary N. Foulks, Fred Sanfilippo

Research output: Contribution to journalArticle


Forty-six consecutive patients at high risk for corneal graft rejection because of significant vascularization or previous graft rejection received transplanted corneas from donors who were selected on the basis of a negative lymphocyte crossmatch, ABO antigen blood group compatibility, and maximized HLA-A and HLA-B antigen matching. Graft survival in this study group was compared to that in a retrospective control group of 71 consecutive high-risk transplants performed in patients receiving corneas obtained randomly. We found no differences between groups in terms of demographic factors, cause of primary corneal disease, or the incidence of previous graft rejection. However, graft survival in the control group was only 49% (35 of 71) vs 83% (38 of 46) for the study group (P

Original languageEnglish (US)
Pages (from-to)622-629
Number of pages8
JournalAmerican Journal of Ophthalmology
Issue number5
Publication statusPublished - 1982
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

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