Beneficial effect of propranolol in a histologically appropriate model of postischemic acute renal failure

K. Solez, R. J. D'Agostini, L. Stawowy, M. T. Freedman, W. W. Scott, S. S. Siegelman, R. H. Heptinstall

Research output: Contribution to journalArticle

Abstract

Acute renal failure caused in the rabbit by clamping one renal pedicle for 1 hr and removing the opposite kidney produced a histologic picture very similar to that observed in ''hypotensive'' acute renal failure in man. Intravenous infusion of propranolol, a drug which prevents renin release, at 1 mg/kg for 70 min beginning at time of pedicle clamping resulted in significantly lower serum creatinine in this model (2.8 ± 0.2 mg% at 48 hr with propranolol versus 5.2 ± 0.8 mg% without). Renin stimulation by dehydration or feeding a low salt diet enhanced the difference between treated and untreated groups (2.6 ± 0.4 mg% with propranolol versus 6.2 ± 1.8 mg% without, after dehydration; 3.5 ± 1.0 mg% with propranolol versus 7.6 ± 1.4 mg% without, after low salt diet). Suppression of renin production by saline feeding eliminated propranolol's beneficial effect (5.6 ± 0.9 mg% with propranolol versus 4.0 ± 0.6 mg% without). In rabbits with a normal food and water intake, renal denervation using phenol also eliminated propranolol's effect (creatinine 8.6 ± 1.4 mg% with propranolol versus 8.6 ± 1.8 mg% without). In rabbits with intact kidneys, flow probe recording of renal blood flow showed a significantly higher blood flow immediately after unclamping in the propranolol treated animals, and renal angiograms showed less vasoconstriction in this group after unclamping. In this model of acute renal failure, renal vasoconstriction plays an important role following the initial ischemic insult. Propranolol lessens the severity of this vasoconstriction and the resulting acute renal failure. Its probable action is interference with neurogenically stimulated renin release.

Original languageEnglish (US)
Pages (from-to)163-185
Number of pages23
JournalAmerican Journal of Pathology
Volume88
Issue number1
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Beneficial effect of propranolol in a histologically appropriate model of postischemic acute renal failure'. Together they form a unique fingerprint.

  • Cite this

    Solez, K., D'Agostini, R. J., Stawowy, L., Freedman, M. T., Scott, W. W., Siegelman, S. S., & Heptinstall, R. H. (1977). Beneficial effect of propranolol in a histologically appropriate model of postischemic acute renal failure. American Journal of Pathology, 88(1), 163-185.