TY - JOUR
T1 - Beneficial effect of long-term beta blockade after acute myocardial infarction in patients without anterograde flow in the infarct artery
AU - Glamann, D. Brent
AU - Lange, Richard A.
AU - Hillis, L. David
PY - 1991/7/15
Y1 - 1991/7/15
N2 - Previous studies have shown that long-term survival after acute myocardial infarction (AMI) is improved by β-adrenergic blockade and anterograde flow in the infarct artery. This study was done to assess the influence of β blockade on mortality in survivors of AMI without anterograde flow. Over 9.5 years, 113 subjects (87 men and 26 women, aged 26 to 66 years) with AMI and no anterograde flow in the infarct artery and no disease of the other arteries were medically treated for 48 ± 28 (mean ± standard deviation) months. Forty-six patients received long-term β blockade (group I), whereas 67 did not (group II). The groups were similar in age, sex, cardioactive medications, left ventricular performance and infarct artery. Of the 46 group I subjects, 1 (2%) died of cardiac causes; in contrast, 20 (30%) of the group II patients died of cardiac causes (p = 0.007 compared with group I). Thus, in survivors of AMI without anterograde flow in the infarct artery, mortality is markedly reduced by long-term β blockade.
AB - Previous studies have shown that long-term survival after acute myocardial infarction (AMI) is improved by β-adrenergic blockade and anterograde flow in the infarct artery. This study was done to assess the influence of β blockade on mortality in survivors of AMI without anterograde flow. Over 9.5 years, 113 subjects (87 men and 26 women, aged 26 to 66 years) with AMI and no anterograde flow in the infarct artery and no disease of the other arteries were medically treated for 48 ± 28 (mean ± standard deviation) months. Forty-six patients received long-term β blockade (group I), whereas 67 did not (group II). The groups were similar in age, sex, cardioactive medications, left ventricular performance and infarct artery. Of the 46 group I subjects, 1 (2%) died of cardiac causes; in contrast, 20 (30%) of the group II patients died of cardiac causes (p = 0.007 compared with group I). Thus, in survivors of AMI without anterograde flow in the infarct artery, mortality is markedly reduced by long-term β blockade.
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U2 - 10.1016/0002-9149(91)90735-4
DO - 10.1016/0002-9149(91)90735-4
M3 - Article
C2 - 1676557
AN - SCOPUS:0025771047
SN - 0002-9149
VL - 68
SP - 150
EP - 154
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 2
ER -