Behavioural assessment of mice lacking D(1A) dopamine receptors

D. R. Smith, C. D. Striplin, A. M. Geller, R. B. Mailman, J. Drago, C. P. Lawler, Michela Gallagher

Research output: Contribution to journalArticle

Abstract

Dopamine D(1A) receptor-deficient mice were assessed in a wide variety of tasks chosen to reflect the diverse roles of this receptor subtype in behavioural regulation. The protocol included examination of exploration and locomotor activity in an open field, a test of sensorimotor orienting, both place and cue learning in the Morris water maze, and assessment of simple associative learning in an olfactory discrimination task. Homozygous mice showed broad-based impairments that were characterized by deficiencies in initiating movement and/or reactivity to external stimuli. Data obtained from flash evoked potentials indicated that these deficits did not reflect gross visual impairments. The partial reduction in D(1A) receptors in the heterozygous mice did not affect performance in most tasks, although circumscribed deficits in some tasks were observed (e.g., failure to develop a reliable spatial bias in the water maze). These findings extend previous behavioural studies of null mutant mice lacking D(1A) receptors and provide additional support for the idea that the D(1A) receptor participates in a wide variety of behavioural functions. The selective impairments of heterozygous mice in a spatial learning task suggest that the hippocampal/cortical dopaminergic system may be uniquely vulnerable to the partial loss of the D(1A) receptor.

Original languageEnglish (US)
Pages (from-to)135-146
Number of pages12
JournalNeuroscience
Volume86
Issue number1
DOIs
StatePublished - May 21 1998
Externally publishedYes

Fingerprint

Dopamine Receptors
Learning
Water
Vision Disorders
Locomotion
Evoked Potentials
Cues
Dopamine

Keywords

  • D(1A) dopamine receptor
  • Knockout
  • Locomotion
  • Morris water maze
  • Sensorimotor
  • Transgenic mice

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Smith, D. R., Striplin, C. D., Geller, A. M., Mailman, R. B., Drago, J., Lawler, C. P., & Gallagher, M. (1998). Behavioural assessment of mice lacking D(1A) dopamine receptors. Neuroscience, 86(1), 135-146. https://doi.org/10.1016/S0306-4522(97)00608-8

Behavioural assessment of mice lacking D(1A) dopamine receptors. / Smith, D. R.; Striplin, C. D.; Geller, A. M.; Mailman, R. B.; Drago, J.; Lawler, C. P.; Gallagher, Michela.

In: Neuroscience, Vol. 86, No. 1, 21.05.1998, p. 135-146.

Research output: Contribution to journalArticle

Smith, DR, Striplin, CD, Geller, AM, Mailman, RB, Drago, J, Lawler, CP & Gallagher, M 1998, 'Behavioural assessment of mice lacking D(1A) dopamine receptors', Neuroscience, vol. 86, no. 1, pp. 135-146. https://doi.org/10.1016/S0306-4522(97)00608-8
Smith DR, Striplin CD, Geller AM, Mailman RB, Drago J, Lawler CP et al. Behavioural assessment of mice lacking D(1A) dopamine receptors. Neuroscience. 1998 May 21;86(1):135-146. https://doi.org/10.1016/S0306-4522(97)00608-8
Smith, D. R. ; Striplin, C. D. ; Geller, A. M. ; Mailman, R. B. ; Drago, J. ; Lawler, C. P. ; Gallagher, Michela. / Behavioural assessment of mice lacking D(1A) dopamine receptors. In: Neuroscience. 1998 ; Vol. 86, No. 1. pp. 135-146.
@article{291948ba2303411bbe221a785b8ceeaf,
title = "Behavioural assessment of mice lacking D(1A) dopamine receptors",
abstract = "Dopamine D(1A) receptor-deficient mice were assessed in a wide variety of tasks chosen to reflect the diverse roles of this receptor subtype in behavioural regulation. The protocol included examination of exploration and locomotor activity in an open field, a test of sensorimotor orienting, both place and cue learning in the Morris water maze, and assessment of simple associative learning in an olfactory discrimination task. Homozygous mice showed broad-based impairments that were characterized by deficiencies in initiating movement and/or reactivity to external stimuli. Data obtained from flash evoked potentials indicated that these deficits did not reflect gross visual impairments. The partial reduction in D(1A) receptors in the heterozygous mice did not affect performance in most tasks, although circumscribed deficits in some tasks were observed (e.g., failure to develop a reliable spatial bias in the water maze). These findings extend previous behavioural studies of null mutant mice lacking D(1A) receptors and provide additional support for the idea that the D(1A) receptor participates in a wide variety of behavioural functions. The selective impairments of heterozygous mice in a spatial learning task suggest that the hippocampal/cortical dopaminergic system may be uniquely vulnerable to the partial loss of the D(1A) receptor.",
keywords = "D(1A) dopamine receptor, Knockout, Locomotion, Morris water maze, Sensorimotor, Transgenic mice",
author = "Smith, {D. R.} and Striplin, {C. D.} and Geller, {A. M.} and Mailman, {R. B.} and J. Drago and Lawler, {C. P.} and Michela Gallagher",
year = "1998",
month = "5",
day = "21",
doi = "10.1016/S0306-4522(97)00608-8",
language = "English (US)",
volume = "86",
pages = "135--146",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Behavioural assessment of mice lacking D(1A) dopamine receptors

AU - Smith, D. R.

AU - Striplin, C. D.

AU - Geller, A. M.

AU - Mailman, R. B.

AU - Drago, J.

AU - Lawler, C. P.

AU - Gallagher, Michela

PY - 1998/5/21

Y1 - 1998/5/21

N2 - Dopamine D(1A) receptor-deficient mice were assessed in a wide variety of tasks chosen to reflect the diverse roles of this receptor subtype in behavioural regulation. The protocol included examination of exploration and locomotor activity in an open field, a test of sensorimotor orienting, both place and cue learning in the Morris water maze, and assessment of simple associative learning in an olfactory discrimination task. Homozygous mice showed broad-based impairments that were characterized by deficiencies in initiating movement and/or reactivity to external stimuli. Data obtained from flash evoked potentials indicated that these deficits did not reflect gross visual impairments. The partial reduction in D(1A) receptors in the heterozygous mice did not affect performance in most tasks, although circumscribed deficits in some tasks were observed (e.g., failure to develop a reliable spatial bias in the water maze). These findings extend previous behavioural studies of null mutant mice lacking D(1A) receptors and provide additional support for the idea that the D(1A) receptor participates in a wide variety of behavioural functions. The selective impairments of heterozygous mice in a spatial learning task suggest that the hippocampal/cortical dopaminergic system may be uniquely vulnerable to the partial loss of the D(1A) receptor.

AB - Dopamine D(1A) receptor-deficient mice were assessed in a wide variety of tasks chosen to reflect the diverse roles of this receptor subtype in behavioural regulation. The protocol included examination of exploration and locomotor activity in an open field, a test of sensorimotor orienting, both place and cue learning in the Morris water maze, and assessment of simple associative learning in an olfactory discrimination task. Homozygous mice showed broad-based impairments that were characterized by deficiencies in initiating movement and/or reactivity to external stimuli. Data obtained from flash evoked potentials indicated that these deficits did not reflect gross visual impairments. The partial reduction in D(1A) receptors in the heterozygous mice did not affect performance in most tasks, although circumscribed deficits in some tasks were observed (e.g., failure to develop a reliable spatial bias in the water maze). These findings extend previous behavioural studies of null mutant mice lacking D(1A) receptors and provide additional support for the idea that the D(1A) receptor participates in a wide variety of behavioural functions. The selective impairments of heterozygous mice in a spatial learning task suggest that the hippocampal/cortical dopaminergic system may be uniquely vulnerable to the partial loss of the D(1A) receptor.

KW - D(1A) dopamine receptor

KW - Knockout

KW - Locomotion

KW - Morris water maze

KW - Sensorimotor

KW - Transgenic mice

UR - http://www.scopus.com/inward/record.url?scp=0031842043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031842043&partnerID=8YFLogxK

U2 - 10.1016/S0306-4522(97)00608-8

DO - 10.1016/S0306-4522(97)00608-8

M3 - Article

VL - 86

SP - 135

EP - 146

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 1

ER -