Behavioral toxicity of cadmium in rats in relation to the level of protein nutrition

M. Mohamed Ali, Bachchu Lal, Neeraj Mathur, S. V. Chandra

Research output: Contribution to journalArticlepeer-review

Abstract

The behavioral toxicity of cadmium (Cd, 100 ppm, through drinking water for 60 days) was assessed in growing male rats maintained on diets containing 21, 8 and 5% protein. Cd exposure in the 21% protein diet fed rats resulted in decreased body weight and growth, spontaneous locomotor activity and learning ability. The response latency in the learning situation was enhanced significantly. The decreases in the locomotor activity and learning ability were more marked in the 5% protein diet fed animals. The increase in the response latency was, however, more marked in the 8% protein diet fed group. Data indicate the enhanced vulnerability of protein malnourished animals to the behavioral deficits induced by Cd.

Original languageEnglish (US)
Pages (from-to)325-335
Number of pages11
JournalNutrition Research
Volume11
Issue number4
DOIs
StatePublished - Apr 1991
Externally publishedYes

Keywords

  • Protein malnutrition
  • behavioral deficits
  • cadmium
  • rat

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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