Behavioral Side Effects of Fluoxetine in Children and Adolescents

Mark A Riddle, Robert A. King, Maureen T. Hardin, Lawrence Scahill, Sharon I. Ort, Phillip Chappell, Ann Rasmusson, James F. Leckman

Research output: Contribution to journalArticle

Abstract

Twelve (50%) of 24 children, ages 8 to 16 years, treated with fluoxetine, 20 or 40 mg/day, for depressive or obsessive compulsive symptoms, developed behavioral side effects characterized by motor restlessness (n = 11), sleep disturbance (n = 11), social disinhibition (n = 6), or a subjective sensation of excitation (n = 3). No major changes in the neurological status of these children were observed. However, the three children with ADHD showed an exacerbation of symptoms on fluoxetine. Discontinuation (n = 5) or halving the dosage (n = 7) resulted in complete resolution of these unwanted symptoms within 1 to 2 weeks. In all 7 children whose doses were reduced, improvement of the depressive or obsessive compulsive symptoms was maintained on the lower dosage. Clinicians treating children with fluoxetine are cautioned to be aware of behavioral side effects which may be alleviated by dosage reduction or possibly by starting with lower doses. These side effects may be difficult to differentiate from common psychopathological symptoms such as hyperactivity, restlessness, and impulsivity.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalJournal of Child and Adolescent Psychopharmacology
Volume1
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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Fluoxetine
Psychomotor Agitation
Behavioral Symptoms
Impulsive Behavior
Sleep

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Riddle, M. A., King, R. A., Hardin, M. T., Scahill, L., Ort, S. I., Chappell, P., ... Leckman, J. F. (1990). Behavioral Side Effects of Fluoxetine in Children and Adolescents. Journal of Child and Adolescent Psychopharmacology, 1(3), 193-198. https://doi.org/10.1089/cap.1990.1.193

Behavioral Side Effects of Fluoxetine in Children and Adolescents. / Riddle, Mark A; King, Robert A.; Hardin, Maureen T.; Scahill, Lawrence; Ort, Sharon I.; Chappell, Phillip; Rasmusson, Ann; Leckman, James F.

In: Journal of Child and Adolescent Psychopharmacology, Vol. 1, No. 3, 1990, p. 193-198.

Research output: Contribution to journalArticle

Riddle, MA, King, RA, Hardin, MT, Scahill, L, Ort, SI, Chappell, P, Rasmusson, A & Leckman, JF 1990, 'Behavioral Side Effects of Fluoxetine in Children and Adolescents', Journal of Child and Adolescent Psychopharmacology, vol. 1, no. 3, pp. 193-198. https://doi.org/10.1089/cap.1990.1.193
Riddle, Mark A ; King, Robert A. ; Hardin, Maureen T. ; Scahill, Lawrence ; Ort, Sharon I. ; Chappell, Phillip ; Rasmusson, Ann ; Leckman, James F. / Behavioral Side Effects of Fluoxetine in Children and Adolescents. In: Journal of Child and Adolescent Psychopharmacology. 1990 ; Vol. 1, No. 3. pp. 193-198.
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