Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia

Meng Xia, Sofya Abazyan, Yan Jouroukhin, Mikhail Pletnikov

Research output: Contribution to journalReview articlepeer-review

Abstract

Astrocytes regulate multiple processes in the brain ranging from trophic support of developing neurons to modulation of synaptic neurotransmission and neuroinflammation in adulthood. It is, therefore, understandable that pathogenesis and pathophysiology of major psychiatric disorders involve astrocyte dysfunctions. Until recently, there has been the paucity of experimental approaches to studying the roles of astrocytes in behavioral disease. A new generation of in vivo models allows us to advance our understanding of the roles of astrocytes in psychiatric disorders. This review will evaluate the recent studies that focus on the contribution of astrocyte dysfunction to behavioral alterations pertinent to schizophrenia and will propose the possible solutions of the limitations of the existing approaches.

Original languageEnglish (US)
Pages (from-to)72-82
Number of pages11
JournalSchizophrenia Research
Volume176
Issue number1
DOIs
StatePublished - Sep 1 2016

Keywords

  • Glutamate
  • Neuroinflammation
  • Neuron–astrocyte interaction
  • Psychiatric disorders
  • Tripartite synapse

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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