Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs

Nanna Marie Lind, Albert Gjedde, Anette Moustgaard, Aage Kristian Olsen, Svend Borup Jensen, Steen Jakobsen, Sidse Marie Arnfred, Axel Kornerup Hansen, Ralf Peter Hemmingsen, Paul Cumming

Research output: Contribution to journalArticle

Abstract

Behavioral response to novelty in rats has been linked both to dopamine transmission in the ventral striatum, and to propensity to self-administer psychostimulant drugs. In order to probe the relationship between behavioral response to novelty and dopamine systems we have developed a behavioral model for correlation with positron emission tomography (PET) of dopamine transmission in brain of Göttingen minipigs. In the present study, we measured exploration of a novel object by recording the number of contacts, and duration of contact with a novel object, in groups of six male and six female adult minipigs. We hypothesized that these novelty scores would correlate with the amphetamine-evoked dopamine release in ventral striatum, measured 2 weeks later in a PET study of the availability of binding sites for the dopamine D 2/3 antagonist [11C]raclopride. There were significant correlations between duration of contact with a novel object and the amphetamine-evoked reductions in binding potential (ΔpB) in the left ventral striatum of the 12 animals; Comparison of results by gender revealed that the correlation was driven mainly by the male group, and was not present in the female group. We interpret these results to show that propensity to explore an unfamiliar object is relatively elevated in pigs with low basal occupancy of dopamine D2/3 receptors by endogenous dopamine, and with high amphetamine-induced occupancy of released dopamine in the male pigs.

Original languageEnglish (US)
Pages (from-to)172-177
Number of pages6
JournalBehavioural Brain Research
Volume164
Issue number2
DOIs
StatePublished - Nov 7 2005
Externally publishedYes

Fingerprint

Miniature Swine
Dopamine Receptors
Dopamine
Amphetamine
Positron-Emission Tomography
Swine
Raclopride
Dopamine D2 Receptors
Binding Sites
Brain
Pharmaceutical Preparations

Keywords

  • [C]raclopride
  • Amphetamine
  • Behavior
  • Dopamine receptors
  • Gender
  • Novelty seeking
  • Personality
  • Pig

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Lind, N. M., Gjedde, A., Moustgaard, A., Olsen, A. K., Jensen, S. B., Jakobsen, S., ... Cumming, P. (2005). Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs. Behavioural Brain Research, 164(2), 172-177. https://doi.org/10.1016/j.bbr.2005.06.008

Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs. / Lind, Nanna Marie; Gjedde, Albert; Moustgaard, Anette; Olsen, Aage Kristian; Jensen, Svend Borup; Jakobsen, Steen; Arnfred, Sidse Marie; Hansen, Axel Kornerup; Hemmingsen, Ralf Peter; Cumming, Paul.

In: Behavioural Brain Research, Vol. 164, No. 2, 07.11.2005, p. 172-177.

Research output: Contribution to journalArticle

Lind, NM, Gjedde, A, Moustgaard, A, Olsen, AK, Jensen, SB, Jakobsen, S, Arnfred, SM, Hansen, AK, Hemmingsen, RP & Cumming, P 2005, 'Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs', Behavioural Brain Research, vol. 164, no. 2, pp. 172-177. https://doi.org/10.1016/j.bbr.2005.06.008
Lind, Nanna Marie ; Gjedde, Albert ; Moustgaard, Anette ; Olsen, Aage Kristian ; Jensen, Svend Borup ; Jakobsen, Steen ; Arnfred, Sidse Marie ; Hansen, Axel Kornerup ; Hemmingsen, Ralf Peter ; Cumming, Paul. / Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs. In: Behavioural Brain Research. 2005 ; Vol. 164, No. 2. pp. 172-177.
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