Abstract
Transplantation of fetal striatal tissue into rats with kainic acid lesions of the striatum reversed the spontaneous locomotor abnormalities caused by the lesions, but had no effect on the lesion-induced hyperactivity that followed amphetamine or apomorphine injection. Conversely, transplants into intact (non-lesioned) striatum led to abnormalities in spontaneous locomotion, but did not effect locomotion under amphetamine or apomorphine conditions. Dopamine autoradiography found a relative absence of dopamine receptors within the transplants. These results suggest that the mechanism which accounts for transplant-induced recovery of spontaneous locomotion is independent of striatal dopamine mechanisms.
Original language | English (US) |
---|---|
Pages (from-to) | 383-385 |
Number of pages | 3 |
Journal | Brain research |
Volume | 363 |
Issue number | 2 |
DOIs | |
State | Published - Jan 22 1986 |
Keywords
- autoradiography
- behavioral recovery
- brain transplant
- dopamine
- kainic acid
- striatum
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology