Behavioral recovery following kainic acid lesions and fetal implants of the striatum occurs independent of dopaminergic mechanisms

A. W. Deckel, T. H. Moran, R. G. Robinson

Research output: Contribution to journalArticle

Abstract

Transplantation of fetal striatal tissue into rats with kainic acid lesions of the striatum reversed the spontaneous locomotor abnormalities caused by the lesions, but had no effect on the lesion-induced hyperactivity that followed amphetamine or apomorphine injection. Conversely, transplants into intact (non-lesioned) striatum led to abnormalities in spontaneous locomotion, but did not effect locomotion under amphetamine or apomorphine conditions. Dopamine autoradiography found a relative absence of dopamine receptors within the transplants. These results suggest that the mechanism which accounts for transplant-induced recovery of spontaneous locomotion is independent of striatal dopamine mechanisms.

Original languageEnglish (US)
Pages (from-to)383-385
Number of pages3
JournalBrain research
Volume363
Issue number2
DOIs
StatePublished - Jan 22 1986

Keywords

  • autoradiography
  • behavioral recovery
  • brain transplant
  • dopamine
  • kainic acid
  • striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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