Behavioral performance effects of verapamil in normotensive and renovascular hypertensive baboons

Jaylan S. Turkkan, Robert D. Hienz

Research output: Contribution to journalArticle

Abstract

Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with verapamil. Performances during a five-color simultaneous match-to-sample task were measured for two doses (2.0, and 3.2 mg/kg/day) and vehicle. Each dose was administered for 21 consecutive days preceded and followed by 14-day baseline and recovery periods, respectively. Choice reaction times increased by 9% during the lower dose of verapamil, compared to vehicle; choice reaction times were unchanged at the higher dose. At baseline and during vehicle administration, the yellow and white stimuli were the most difficult to discriminate correctly; discrimination of these colors was slightly impaired by the lower, but not the higher dose of verapamil. Verapamil's behavioral effects were not modulated by blood pressure changes since both baboon groups showed equivalent changes in behavioral performance, but only renovascular hypertensive baboons showed blood pressure decreases. Verapamil appears to be an effective hypotensive and does not produce profound psychomotor impairment at clinically used doses during the first weeks of treatment.

Original languageEnglish (US)
Pages (from-to)142-150
Number of pages9
JournalIntegrative Physiological and Behavioral Science
Volume27
Issue number2
DOIs
StatePublished - Apr 1992

Keywords

  • adverse side-effects
  • antihypertensive agents
  • blood pressure
  • calcium channel blocking agents
  • choice reaction time
  • color discrimination
  • hypertension
  • non-human primates
  • verapamil

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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