Behavioral effects of nicotine, amphetamine and cocaine under a fixed- interval schedule of food reinforcement in rats chronically exposed to caffeine

Maria Jaszyna, Maciej Gasior, Mohammed Shoaib, Sevil Yasar, Steven R. Goldberg

Research output: Contribution to journalArticle

Abstract

Epidemiological surveys demonstrate that caffeine, the main psychoactive ingredient of coffee, is a positive correlate in drug abuse. To characterize the behavioral nature of caffeine interactions with other psychomotor stimulants, we examined the effects of chronic caffeine exposure on the behavioral responses to nicotine, amphetamine, cocaine, the selective D agonist SKF-82958 and the selective D2 receptor agonist NPA, in rats responding under a fixed interval (FI) schedule of food reinforcement. Following stabilization of rates and temporal patterns of responding (mathematically expressed as quarter-life values, QL), twenty-one Sprague- Dawley rats responding under a 5-min FI schedule of food reinforcement were divided into two groups; one (twelve rats) maintained on tap water (control) and the other (nine rats) on caffeine (3 mg/ml added to the drinking water). Following the substitution of caffeine solution for tap water, behavior was temporarily disrupted as evidenced by decreases in responding and QL values which reached a maximum after 72 h (rate 60% and QL 30% below baseline levels). Rats developed complete tolerance to these effects of caffeine over 5 days of caffeine exposure. After response rate and QL values stabilized, effects of drugs were evaluated. Nicotine (0.01-1.0 mg/kg; SC), amphetamine (0.1-5.6; IP), and cocaine (1.0-17; IP) each produced biphasic dose-dependent changes in response rate with maximum increases in response rate following intermediate doses and decreases in response rates following higher doses. The increase in rates of responding produced by amphetamine or cocaine (but not nicotine) were greater (P0.05) were produced by NPA in both groups. Except for amphetamine, the remaining drugs produced similar (P>0.05) dose-dependent decreases in QL values in water- and caffeine-drinking rats. Amphetamine produced smaller decreases in QL values in caffeine-drinking rats than in water-drinking rats (P

Original languageEnglish (US)
Pages (from-to)257-271
Number of pages15
JournalPsychopharmacology
Volume140
Issue number3
DOIs
StatePublished - 1998

Fingerprint

Reinforcement Schedule
Amphetamine
Caffeine
Nicotine
Cocaine
Food
Drinking Water
Value of Life
Water
Coffee
Pharmaceutical Preparations
Drinking
Substance-Related Disorders
Sprague Dawley Rats

Keywords

  • Amphetamine
  • Caffeine
  • Cocaine
  • Drug interaction
  • Nicotine
  • Rat
  • Schedule- controlled behavior

ASJC Scopus subject areas

  • Pharmacology

Cite this

Behavioral effects of nicotine, amphetamine and cocaine under a fixed- interval schedule of food reinforcement in rats chronically exposed to caffeine. / Jaszyna, Maria; Gasior, Maciej; Shoaib, Mohammed; Yasar, Sevil; Goldberg, Steven R.

In: Psychopharmacology, Vol. 140, No. 3, 1998, p. 257-271.

Research output: Contribution to journalArticle

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