Behavioral effects of clomipramine on prepubertal boys with autistic disorder and severe mental retardation

James Robert Brasic, Jacqueline Y. Barnett, Brian B. Sheitman, R. Todd Lafargue, S. Kowalik, Diana Kaplan, Margaret Owen Tsaltas, Raheela Ahmad, Robert H. Nadrich, Maria Fatima De Mendonça

Research output: Contribution to journalReview article

Abstract

In an open nonblind clinical trial, clomipramine was administered to five previously medicated prepubertal boys with autistic disorder and severe mental retardation unmanageable due to behavior and motor problems. Although all five boys initially displayed marked behavioral symptom reduction, they developed behavioral neurotoxicity necessitating discontinuation of clomipramine for all five and immediate hospitalization for three. Serious adverse effects included increased seizure frequency and symptoms of a serotonin syndrome. Our findings indicate that clomipramine enhances adaptive behavior and produces serious adverse effects in severely retarded autistic children whose symptoms were complicated by dyskinesias.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalCNS spectrums
Volume3
Issue number10
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Brasic, J. R., Barnett, J. Y., Sheitman, B. B., Todd Lafargue, R., Kowalik, S., Kaplan, D., Tsaltas, M. O., Ahmad, R., Nadrich, R. H., & De Mendonça, M. F. (1998). Behavioral effects of clomipramine on prepubertal boys with autistic disorder and severe mental retardation. CNS spectrums, 3(10), 39-46. https://doi.org/10.1017/S1092852900006647