Abstract
Behavioral performances of six baboons were tested during chronic oral dosing with diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Reaction times and color matching-to-sample performances as well as physiological measures were obtained in deoxycorticosterone acetate (DOCA)-salt baboons and in renovascular hypertensive baboons. Combined diuretic and verapamil impaired color matching to a small degree in comparison to baseline performance, while drug administered alone had no effect. Weekly systolic and diastolic blood pressures decreased maximally from baseline during the drug combination period, and were accompanied by maximal increases in serum sodium. The largest behavioral impairments during combination dosing were observed for colors that were most difficult to discriminate during baseline. Significant positive correlations were found between systolic blood pressure and color matching accuracy. No differences between the animal hypertension groups were found as a function of drug condition either in physiological or behavioral responses. Only the combination of diuretic and verapamil produced a deleterious effect on color discrimination, which suggests further study of commonly administered drug combination therapies in hypertension.
Original language | English (US) |
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Pages (from-to) | 55-62 |
Number of pages | 8 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 38 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1991 |
Externally published | Yes |
Keywords
- Antihypertensive agents-adverse side-effects
- Blood pressure
- Calcium channel blocking agents
- Color discrimination
- DOCA-salt hypertension
- Motor behavior
- Nonhuman primates-baboons
- Renovascular hypertension
- Thiazide diuretics
- Verapamil
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience