Behavioral changes of zebrafish according to cisplatin-induced toxicity of the balance system

M. J. Kim; J. Choi; N. Kim; G. C. Han

doi:10.1177/0960327114521046

Behavioral changes of zebrafish according to cisplatin-induced toxicity of the balance system

M. J. Kim, J. Choi, N. Kim, G. C. Han

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background and objectives: Zebrafish are commonly used as experimental animals in otolaryngology studies. However, the behavioral characteristics of these fish are not well known, especially those related to the vestibular system. The goal of this study was to evaluate behavioral changes in zebrafish due to toxicity in the balance system.

Materials and methods: Zebrafish were exposed to 1000 μM cisplatin for 6 h.We, then, eriodically monitored swimming depth, total swimming distance, peak swimming velocity, and mean swimming velocity of the fish for approximately 21 days.

Results: Total swimming distance (p <0.0001), peak swimming velocity (p = 0.0063), and mean swimming velocity (p <0.0001) in the cisplatin-administered group were significantly decreased when compared with control fish.

Conclusion: Our findings demonstrate that cisplatin can alter the locomotion behavior of zebrafish.

Original language	English (US)
Pages (from-to)	1167-1175
Number of pages	9
Journal	Human and Experimental Toxicology
Volume	33
Issue number	11
DOIs	https://doi.org/10.1177/0960327114521046
State	Published - Nov 11 2014
Externally published	Yes

Keywords

behavior
cisplatin
toxicity
vestibule of ear
Zebrafish

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis
General Medicine

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10.1177/0960327114521046

Cite this

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AU - Kim, M. J.

AU - Choi, J.

AU - Kim, N.

AU - Han, G. C.

PY - 2014/11/11

Y1 - 2014/11/11

N2 - Background and objectives: Zebrafish are commonly used as experimental animals in otolaryngology studies. However, the behavioral characteristics of these fish are not well known, especially those related to the vestibular system. The goal of this study was to evaluate behavioral changes in zebrafish due to toxicity in the balance system.Materials and methods: Zebrafish were exposed to 1000 μM cisplatin for 6 h.We, then, eriodically monitored swimming depth, total swimming distance, peak swimming velocity, and mean swimming velocity of the fish for approximately 21 days.Results: Total swimming distance (p <0.0001), peak swimming velocity (p = 0.0063), and mean swimming velocity (p <0.0001) in the cisplatin-administered group were significantly decreased when compared with control fish.Conclusion: Our findings demonstrate that cisplatin can alter the locomotion behavior of zebrafish.

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Behavioral changes of zebrafish according to cisplatin-induced toxicity of the balance system

Abstract

Keywords

ASJC Scopus subject areas

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