Behavioral and pathological outcomes in MOG 35-55 experimental autoimmune encephalomyelitis

M. V. Jones, T. T. Nguyen, C. A. DeBoy, J. W. Griffin, K. A. Whartenby, D. A. Kerr, P. A. Calabresi

Research output: Contribution to journalArticlepeer-review

Abstract

We measured inflammatory and neural markers of disease from 7 days to one year after induction of experimental autoimmune encephalomyelitis (EAE) by immunization with myelin oligodendrocyte glycoprotein (MOG) peptide. Axon loss began before behavioral signs when T cell infiltration and microglial activation were very subtle. Remyelination was only detectable ultrastructurally. Axon numbers in the dorsal column plateau around day 30 p.i. while behavioral measures (EAE scores, rotarod, grip strength) partially recover. These results provide a starting point for testing potential neuroprotective treatments for multiple sclerosis (MS).

Original languageEnglish (US)
Pages (from-to)83-93
Number of pages11
JournalJournal of Neuroimmunology
Volume199
Issue number1-2
DOIs
StatePublished - Aug 13 2008

Keywords

  • Axons
  • EAE
  • Microglia
  • Multiple sclerosis
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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