Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors

Stephen R. Zukin, Kathleen T. Brady, Barbara L. Slifer, Robert L. Balster

Research output: Contribution to journalArticle

Abstract

The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at μ opiate and σ opiate/phenycyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.

Original languageEnglish (US)
Pages (from-to)174-177
Number of pages4
JournalBrain Research
Volume294
Issue number1
DOIs
StatePublished - Feb 27 1984
Externally publishedYes

Keywords

  • cyclazocine
  • ketamine
  • N-allylnormetazocine
  • opiate receptors
  • phencyclidine
  • phencyclidine receptors
  • sigma opiate

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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