Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors

Stephen R. Zukin, Kathleen T. Brady, Barbara L. Slifer, Robert L. Balster

Research output: Contribution to journalArticle

Abstract

The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at μ opiate and σ opiate/phenycyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.

Original languageEnglish (US)
Pages (from-to)174-177
Number of pages4
JournalBrain Research
Volume294
Issue number1
DOIs
StatePublished - Feb 27 1984
Externally publishedYes

Fingerprint

Opiate Alkaloids
Phencyclidine Receptors
Opioid Receptors
Cyclazocine
Stereoisomerism
Ketamine
Ligands
Brain
In Vitro Techniques
SK&F 10047

Keywords

  • cyclazocine
  • ketamine
  • N-allylnormetazocine
  • opiate receptors
  • phencyclidine
  • phencyclidine receptors
  • sigma opiate

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Zukin, S. R., Brady, K. T., Slifer, B. L., & Balster, R. L. (1984). Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors. Brain Research, 294(1), 174-177. https://doi.org/10.1016/0006-8993(84)91326-X

Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors. / Zukin, Stephen R.; Brady, Kathleen T.; Slifer, Barbara L.; Balster, Robert L.

In: Brain Research, Vol. 294, No. 1, 27.02.1984, p. 174-177.

Research output: Contribution to journalArticle

Zukin, SR, Brady, KT, Slifer, BL & Balster, RL 1984, 'Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors', Brain Research, vol. 294, no. 1, pp. 174-177. https://doi.org/10.1016/0006-8993(84)91326-X
Zukin, Stephen R. ; Brady, Kathleen T. ; Slifer, Barbara L. ; Balster, Robert L. / Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors. In: Brain Research. 1984 ; Vol. 294, No. 1. pp. 174-177.
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