Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors

Stephen R. Zukin; Kathleen T. Brady; Barbara L. Slifer; Robert L. Balster

doi:10.1016/0006-8993(84)91326-X

Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors

Stephen R. Zukin, Kathleen T. Brady, Barbara L. Slifer, Robert L. Balster

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at μ opiate and σ opiate/phenycyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.

Original language	English (US)
Pages (from-to)	174-177
Number of pages	4
Journal	Brain Research
Volume	294
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)91326-X
State	Published - Feb 27 1984
Externally published	Yes

Keywords

cyclazocine
ketamine
N-allylnormetazocine
opiate receptors
phencyclidine
phencyclidine receptors
sigma opiate

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
General Neuroscience

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10.1016/0006-8993(84)91326-X

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title = "Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors",

abstract = "The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at μ opiate and σ opiate/phenycyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.",

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language = "English (US)",

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T1 - Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors

AU - Zukin, Stephen R.

AU - Brady, Kathleen T.

AU - Slifer, Barbara L.

AU - Balster, Robert L.

PY - 1984/2/27

Y1 - 1984/2/27

N2 - The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at μ opiate and σ opiate/phenycyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.

AB - The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at μ opiate and σ opiate/phenycyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.

KW - cyclazocine

KW - ketamine

KW - N-allylnormetazocine

KW - opiate receptors

KW - phencyclidine

KW - phencyclidine receptors

KW - sigma opiate

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DO - 10.1016/0006-8993(84)91326-X

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JO - Brain Research

JF - Brain Research

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ER -

Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors

Abstract

Keywords

ASJC Scopus subject areas

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