Behavior of the Beeler-Reuter model during rapid re-excitation

Matthew G. Fishler, Nitish V. Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution


An investigation into the behavior of the Beeler-Reuter mathematical model of membrane electrical activity for ventricular myocardial fibers, especially with regard to rapid reexcitation, is presented. Two protocols were used: (a) the response of the model to a sudden change in the pacing interval for various stimulus strengths was analyzed; and (b) the strength-duration characteristics of the model for various coupling intervals were generated. The results indicate that the model is nearly exclusively responsive to the previous diastolic interval, and rather insensitive to the coupling interval. Both the action potential duration and amplitude can be modeled nearly perfectly by one-minus-double-exponential functions of the diastolic interval. However, contrary to some experimental evidence, the model is not reexcitable for cases when the premature stimulus is delivered while the transmembrane potential is greater than approximately -70 mV.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Number of pages2
Editionpt 2
ISBN (Print)0879425598
StatePublished - Dec 1 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 2
ISSN (Print)0589-1019


OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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