Behavior of the Beeler-Reuter model during rapid re-excitation

Matthew G. Fishler, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An investigation into the behavior of the Beeler-Reuter mathematical model of membrane electrical activity for ventricular myocardial fibers, especially with regard to rapid reexcitation, is presented. Two protocols were used: (a) the response of the model to a sudden change in the pacing interval for various stimulus strengths was analyzed; and (b) the strength-duration characteristics of the model for various coupling intervals were generated. The results indicate that the model is nearly exclusively responsive to the previous diastolic interval, and rather insensitive to the coupling interval. Both the action potential duration and amplitude can be modeled nearly perfectly by one-minus-double-exponential functions of the diastolic interval. However, contrary to some experimental evidence, the model is not reexcitable for cases when the premature stimulus is delivered while the transmembrane potential is greater than approximately -70 mV.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
PublisherPubl by IEEE
Pages622-623
Number of pages2
Editionpt 2
ISBN (Print)0879425598
StatePublished - 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

Fingerprint

Exponential functions
Mathematical models
Membranes
Fibers

ASJC Scopus subject areas

  • Bioengineering

Cite this

Fishler, M. G., & Thakor, N. V. (1990). Behavior of the Beeler-Reuter model during rapid re-excitation. In Proceedings of the Annual Conference on Engineering in Medicine and Biology (pt 2 ed., pp. 622-623). Publ by IEEE.

Behavior of the Beeler-Reuter model during rapid re-excitation. / Fishler, Matthew G.; Thakor, Nitish V.

Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2. ed. Publ by IEEE, 1990. p. 622-623.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fishler, MG & Thakor, NV 1990, Behavior of the Beeler-Reuter model during rapid re-excitation. in Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 edn, Publ by IEEE, pp. 622-623, Proceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Philadelphia, PA, USA, 11/1/90.
Fishler MG, Thakor NV. Behavior of the Beeler-Reuter model during rapid re-excitation. In Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 ed. Publ by IEEE. 1990. p. 622-623
Fishler, Matthew G. ; Thakor, Nitish V. / Behavior of the Beeler-Reuter model during rapid re-excitation. Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2. ed. Publ by IEEE, 1990. pp. 622-623
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