Behavior maintained by alfentanil or nalbuphine in rhesus monkeys

Fixed-ratio and time-out changes to establish demand curves and relative reinforcing effectiveness

Gail Winger, James H. Woods, Steven R. Hursh

Research output: Contribution to journalArticle

Abstract

A fixed-ratio, time-out schedule of intravenous alfentanil or nalbuphine delivery was used to maintain responding in rhesus monkeys (Macaca mulatta) during twice-daily 2-hr sessions of unrestricted access. Four doses of each drug were tested under 10 response fixed-ratio and 10-s time-out baseline conditions. Either the fixed ratio or the time-out was periodically increased during single sessions. Alfentanil maintained higher response rates than nalbuphine under conditions in which response rates were limited by the size of the fixed ratio rather than by unconditioned effects. This indicates that alfentanil is a more effective reinforcer than nalbuphine, which is predicted on the basis of the greater intrinsic efficacy of alfentanil relative to nalbuphine at the mu opioid receptor. Unit price analysis of these data demonstrated that a single demand function could be drawn for each drug, indicating that for these opioids in this situation, increasing the dose per injection was equivalent to decreasing the fixed ratio.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalExperimental and Clinical Psychopharmacology
Volume4
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Nalbuphine
Alfentanil
Macaca mulatta
mu Opioid Receptor
Pharmaceutical Preparations
Opioid Analgesics
Appointments and Schedules
Injections

ASJC Scopus subject areas

  • Pharmacology
  • Experimental and Cognitive Psychology

Cite this

Behavior maintained by alfentanil or nalbuphine in rhesus monkeys : Fixed-ratio and time-out changes to establish demand curves and relative reinforcing effectiveness. / Winger, Gail; Woods, James H.; Hursh, Steven R.

In: Experimental and Clinical Psychopharmacology, Vol. 4, No. 2, 1996, p. 131-140.

Research output: Contribution to journalArticle

@article{ca3f5dc3956443b6a34545228cf2c437,
title = "Behavior maintained by alfentanil or nalbuphine in rhesus monkeys: Fixed-ratio and time-out changes to establish demand curves and relative reinforcing effectiveness",
abstract = "A fixed-ratio, time-out schedule of intravenous alfentanil or nalbuphine delivery was used to maintain responding in rhesus monkeys (Macaca mulatta) during twice-daily 2-hr sessions of unrestricted access. Four doses of each drug were tested under 10 response fixed-ratio and 10-s time-out baseline conditions. Either the fixed ratio or the time-out was periodically increased during single sessions. Alfentanil maintained higher response rates than nalbuphine under conditions in which response rates were limited by the size of the fixed ratio rather than by unconditioned effects. This indicates that alfentanil is a more effective reinforcer than nalbuphine, which is predicted on the basis of the greater intrinsic efficacy of alfentanil relative to nalbuphine at the mu opioid receptor. Unit price analysis of these data demonstrated that a single demand function could be drawn for each drug, indicating that for these opioids in this situation, increasing the dose per injection was equivalent to decreasing the fixed ratio.",
author = "Gail Winger and Woods, {James H.} and Hursh, {Steven R.}",
year = "1996",
doi = "10.1037/1064-1297.4.2.131",
language = "English (US)",
volume = "4",
pages = "131--140",
journal = "Experimental and Clinical Psychopharmacology",
issn = "1064-1297",
publisher = "American Psychological Association Inc.",
number = "2",

}

TY - JOUR

T1 - Behavior maintained by alfentanil or nalbuphine in rhesus monkeys

T2 - Fixed-ratio and time-out changes to establish demand curves and relative reinforcing effectiveness

AU - Winger, Gail

AU - Woods, James H.

AU - Hursh, Steven R.

PY - 1996

Y1 - 1996

N2 - A fixed-ratio, time-out schedule of intravenous alfentanil or nalbuphine delivery was used to maintain responding in rhesus monkeys (Macaca mulatta) during twice-daily 2-hr sessions of unrestricted access. Four doses of each drug were tested under 10 response fixed-ratio and 10-s time-out baseline conditions. Either the fixed ratio or the time-out was periodically increased during single sessions. Alfentanil maintained higher response rates than nalbuphine under conditions in which response rates were limited by the size of the fixed ratio rather than by unconditioned effects. This indicates that alfentanil is a more effective reinforcer than nalbuphine, which is predicted on the basis of the greater intrinsic efficacy of alfentanil relative to nalbuphine at the mu opioid receptor. Unit price analysis of these data demonstrated that a single demand function could be drawn for each drug, indicating that for these opioids in this situation, increasing the dose per injection was equivalent to decreasing the fixed ratio.

AB - A fixed-ratio, time-out schedule of intravenous alfentanil or nalbuphine delivery was used to maintain responding in rhesus monkeys (Macaca mulatta) during twice-daily 2-hr sessions of unrestricted access. Four doses of each drug were tested under 10 response fixed-ratio and 10-s time-out baseline conditions. Either the fixed ratio or the time-out was periodically increased during single sessions. Alfentanil maintained higher response rates than nalbuphine under conditions in which response rates were limited by the size of the fixed ratio rather than by unconditioned effects. This indicates that alfentanil is a more effective reinforcer than nalbuphine, which is predicted on the basis of the greater intrinsic efficacy of alfentanil relative to nalbuphine at the mu opioid receptor. Unit price analysis of these data demonstrated that a single demand function could be drawn for each drug, indicating that for these opioids in this situation, increasing the dose per injection was equivalent to decreasing the fixed ratio.

UR - http://www.scopus.com/inward/record.url?scp=0029951597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029951597&partnerID=8YFLogxK

U2 - 10.1037/1064-1297.4.2.131

DO - 10.1037/1064-1297.4.2.131

M3 - Article

VL - 4

SP - 131

EP - 140

JO - Experimental and Clinical Psychopharmacology

JF - Experimental and Clinical Psychopharmacology

SN - 1064-1297

IS - 2

ER -