Beat to beat variability in cardiovascular variables: Noise or music?

Marvin L. Appel, Ronald D. Berger, J. Philip Saul, Joseph M. Smith, Richard J. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiovascular variables such as heart rate, arterial blood pressure, stroke volume and the shape of electrocardiographic complexes all fluctuate on a beat to beat basis. These fluctuations have traditionally been ignored or, at best, treated as noise to be averaged out. The variability in cardiovascular signals reflects the homeodynamic interplay between perturbations to cardiovascular function and the dynamic response of the cardiovascular regulatory systems. Modern signal processing techniques provide a means of analyzing beat to beat fluctuations in cardiovascular signals, so as to permit a quantitative, noninvasive or minimally invasive method of assessing closed loop hemodynamic regulation and cardiac electrical stability. This method promises to provide a new approach to the clinical diagnosis and management of alterations in cardiovascular regulation and stability.

Original languageEnglish (US)
Pages (from-to)1139-1148
Number of pages10
JournalJournal of the American College of Cardiology
Volume14
Issue number5
DOIs
StatePublished - Nov 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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