TY - JOUR
T1 - BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
AU - Terracciano, Antonio
AU - Tanaka, Toshiko
AU - Sutin, Angelina R.
AU - Deiana, Barbara
AU - Balaci, Lenuta
AU - Sanna, Serena
AU - Olla, Nazario
AU - Maschio, Andrea
AU - Uda, Manuela
AU - Ferrucci, Luigi
AU - Schlessinger, David
AU - Costa, Paul T.
N1 - Funding Information:
Ogliastra), the mayors of the four Sardinian towns (Lanusei, Ilbono, Arzana, and Elini), and the head of the Public Health Unit ASL4 for cooperation. We thank Professor Antonio Cao for his leadership of the SardiNIA project. This research was supported entirely by the Intramural Research Program of the NIH, National Institute on Aging.
PY - 2010/4
Y1 - 2010/4
N2 - Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurotransmission, and has been linked to neuroticism, a major risk factor for psychiatric disorders. A recent genome-wide association (GWA) scan, however, found the BDNF Val66Met polymorphism (rs6265) associated with extraversion but not with neuroticism. In this study, we examine the links between BDNF and personality traits, assessed using the Revised NEO Personality Inventory (NEO-PI-R), in a sample from SardiNIA (n1560) and the Baltimore Longitudinal Study of Aging (BLSA; n1131). Consistent with GWA results, we found that BDNF Met carriers were more introverted. By contrast, in both samples and in a meta-analysis inclusive of published data (n15251), we found no evidence for a main effect of BDNF Val66Met on neuroticism. Finally, on the basis of recent reports of an epistatic effect between BDNF and the serotonin transporter, we explored a Val66Met × 5-HTTLPR interaction in a larger SardiNIA sample (n2333). We found that 5-HTTLPR LL carriers scored lower on neuroticism in the presence of the BDNF Val variant, but scored higher on neuroticism in the presence of the BDNF Met variant. Our findings support the association between the BDNF Met variant and introversion and suggest that BDNF interacts with the serotonin transporter gene to influence neuroticism.
AB - Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurotransmission, and has been linked to neuroticism, a major risk factor for psychiatric disorders. A recent genome-wide association (GWA) scan, however, found the BDNF Val66Met polymorphism (rs6265) associated with extraversion but not with neuroticism. In this study, we examine the links between BDNF and personality traits, assessed using the Revised NEO Personality Inventory (NEO-PI-R), in a sample from SardiNIA (n1560) and the Baltimore Longitudinal Study of Aging (BLSA; n1131). Consistent with GWA results, we found that BDNF Met carriers were more introverted. By contrast, in both samples and in a meta-analysis inclusive of published data (n15251), we found no evidence for a main effect of BDNF Val66Met on neuroticism. Finally, on the basis of recent reports of an epistatic effect between BDNF and the serotonin transporter, we explored a Val66Met × 5-HTTLPR interaction in a larger SardiNIA sample (n2333). We found that 5-HTTLPR LL carriers scored lower on neuroticism in the presence of the BDNF Val variant, but scored higher on neuroticism in the presence of the BDNF Met variant. Our findings support the association between the BDNF Met variant and introversion and suggest that BDNF interacts with the serotonin transporter gene to influence neuroticism.
KW - BDNF Val66Met
KW - Depression
KW - GWA
KW - Gene-gene interaction.
KW - Personality
KW - Serotonin transporter
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U2 - 10.1038/npp.2009.213
DO - 10.1038/npp.2009.213
M3 - Article
C2 - 20042999
AN - SCOPUS:77949541540
SN - 0893-133X
VL - 35
SP - 1083
EP - 1089
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 5
ER -