BDNF mediates adaptive brain and body responses to energetic challenges

Krisztina Marosi, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

Emerging findings suggest that brain-derived neurotrophic factor (BDNF) serves widespread roles in regulating energy homeostasis by controlling patterns of feeding and physical activity, and by modulating glucose metabolism in peripheral tissues. BDNF mediates the beneficial effects of energetic challenges such as vigorous exercise and fasting on cognition, mood, cardiovascular function, and on peripheral metabolism. By stimulating glucose transport and mitochondrial biogenesis BDNF bolsters cellular bioenergetics and protects neurons against injury and disease. By acting in the brain and periphery, BDNF increases insulin sensitivity and parasympathetic tone. Genetic factors, a 'couch potato' lifestyle, and chronic stress impair BDNF signaling, and this may contribute to the pathogenesis of metabolic syndrome. Novel BDNF-focused interventions are being developed for obesity, diabetes, and neurological disorders.

Original languageEnglish (US)
Pages (from-to)89-98
Number of pages10
JournalTrends in Endocrinology and Metabolism
Volume25
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Alzheimer's disease
  • BDNF
  • Diabetes
  • Exercise
  • Glucocorticoid
  • Insulin resistance
  • Learning and memory
  • Obesity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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