BDNF and 5-HT: A dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

Mark P. Mattson, Stuart Maudsley, Bronwen Martin

Research output: Contribution to journalArticle

Abstract

Brain-derived neurotrophic factor (BDNF) and serotonin (5- hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Impaired 5-HT and BDNF signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, Alzheimer's disease and Huntington's disease. Enhancement of BDNF signaling may be a key mechanism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve brain function during aging. Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging.

Original languageEnglish (US)
Pages (from-to)589-594
Number of pages6
JournalTrends in Neurosciences
Volume27
Issue number10
DOIs
StatePublished - Oct 2004

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ASJC Scopus subject areas

  • Neuroscience(all)

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