TY - JOUR
T1 - BDNF and 5-HT
T2 - A dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
AU - Mattson, Mark P.
AU - Maudsley, Stuart
AU - Martin, Bronwen
PY - 2004/10
Y1 - 2004/10
N2 - Brain-derived neurotrophic factor (BDNF) and serotonin (5- hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Impaired 5-HT and BDNF signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, Alzheimer's disease and Huntington's disease. Enhancement of BDNF signaling may be a key mechanism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve brain function during aging. Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging.
AB - Brain-derived neurotrophic factor (BDNF) and serotonin (5- hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Impaired 5-HT and BDNF signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, Alzheimer's disease and Huntington's disease. Enhancement of BDNF signaling may be a key mechanism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve brain function during aging. Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging.
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U2 - 10.1016/j.tins.2004.08.001
DO - 10.1016/j.tins.2004.08.001
M3 - Article
C2 - 15374669
AN - SCOPUS:4544328810
SN - 0166-2236
VL - 27
SP - 589
EP - 594
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 10
ER -