Abstract
We consider inference for longitudinal data based on mixed-effects models with a non-parametric Bayesian prior on the treatment effect. The proposed non-parametric Bayesian prior is a random partition model with a regression on patient-specific covariates. The main feature and motivation for the proposed model is the use of covariates with a mix of different data formats and possibly high-order interactions in the regression. The regression is not explicitly parameterized. It is implied by the random clustering of subjects. The motivating application is a study of the effect of an anticancer drug on a patient's blood pressure. The study involves blood pressure measurements taken periodically over several 24-h periods for 54 patients. The 24-h periods for each patient include a pretreatment period and several occasions after the start of therapy.
Original language | English (US) |
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Pages (from-to) | 341-352 |
Number of pages | 12 |
Journal | Biostatistics |
Volume | 15 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2014 |
Keywords
- Clustering
- Mixed-effects model
- Non-parametric Bayesian model
- Random partition
- Repeated measurement data
ASJC Scopus subject areas
- General Medicine