Basophils in anaphylaxis

David E. Sloane, Donald MacGlashan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human basophils are the least common (and arguably the least well understood) peripheral blood leukocyte. Their roles in normal physiology and homeostasis are unknown, but their ability to bind IgE, to release histamine, leukotrienes, and other mediators, and to move into extravascular tissues suggest that they may participate in allergic reactions, including anaphylaxis. Although basophils share many salient features with mast cells, it is now widely accepted that these are two distinct cell types. Recent evidence from murine models of anaphylaxis indicates a role for basophils in some situations, but if (and, if so, how) basophils contribute to anaphylaxis in humans is as yet undetermined.

Original languageEnglish (US)
Title of host publicationAnaphylaxis and Hypersensitivity Reactions
PublisherHumana Press
Pages69-87
Number of pages19
ISBN (Print)9781603279505
DOIs
StatePublished - Dec 1 2011

Keywords

  • Anaphylaxis
  • Basophil
  • FcεRI
  • IgE receptor
  • Murine model
  • Platelet-activating factor
  • Signal transduction

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Sloane, D. E., & MacGlashan, D. (2011). Basophils in anaphylaxis. In Anaphylaxis and Hypersensitivity Reactions (pp. 69-87). Humana Press. https://doi.org/10.1007/978-1-60327-951-2_5