Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies

John A. Eckman, Robert G Hamilton, Laura M. Gober, Patricia M. Sterba, Sarbjit S Saini

Research output: Contribution to journalArticle

Abstract

Potentially pathogenic IgG autoantibodies to IgE or its receptor, FcεRIα, have been detected in ∼40% of chronic idiopathic urticaria (CIU) patients. CIU patients' basophils display distinct altered FcεRIα-mediated degranulation. CIU patients with basophil histamine release in response to polyclonal goat anti-human IgE ≥10% are classified as CIU responders (CIU-R) and

Original languageEnglish (US)
Pages (from-to)1956-1963
Number of pages8
JournalJournal of Investigative Dermatology
Volume128
Issue number8
DOIs
StatePublished - Aug 2008

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Basophils
Urticaria
Autoantibodies
Immunoglobulin E
Phenotype
Histamine
Immunoglobulin G
Histamine Release
Goats

ASJC Scopus subject areas

  • Dermatology

Cite this

Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies. / Eckman, John A.; Hamilton, Robert G; Gober, Laura M.; Sterba, Patricia M.; Saini, Sarbjit S.

In: Journal of Investigative Dermatology, Vol. 128, No. 8, 08.2008, p. 1956-1963.

Research output: Contribution to journalArticle

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