Basic overview of current immunotherapy approaches in urologic malignancy

Charles G. Drake

Research output: Contribution to journalArticlepeer-review

Abstract

The immune response to evolving prostate cancer is a complex and carefully orchestrated process. Such a response is initiated when immature dendritic cells take up and process tumor-associated antigens. These dendritic cells must then be activated in order to present peptides to helper (CD4) T cells. Cytolytic (CD8) T cells are next "licensed" to achieve full effector function by interacting with both antigen presenting cells and tumor-specific CD4 T cells. Finally, activated CD8 T cells traffic to sites of neoplasia and mediate killing by multiple mechanisms. This article provides a basic overview of these processes, and discusses the manner by which current clinical interventions seek to augment or initiate an antitumor immune response. Various compensatory mechanisms which serve to down-regulate an antitumor response are also examined.

Original languageEnglish (US)
Pages (from-to)413-418
Number of pages6
JournalUrologic Oncology: Seminars and Original Investigations
Volume24
Issue number5
DOIs
StatePublished - Sep 2006

Keywords

  • Immunology
  • Prostate
  • T cell
  • Tumor
  • Vaccine

ASJC Scopus subject areas

  • Oncology
  • Urology

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