Baseline relationships between psoriasis and psoriatic arthritis: Analysis of 221 patients with active psoriatic arthritis

Miriam Richter Cohen, Domenic J. Reda, Daniel O. Clegg

Research output: Contribution to journalArticle

Abstract

Objective. To determine differences in disease onset, extent, and manifestations of psoriasis among patients with active, inflammatory psoriatic arthritis (PsA), and to examine relationships that may exist between psoriasis and PsA. Methods. Baseline demographic, clinical, and laboratory data were analyzed from 221 patients enrolled in a multicenter cooperative study, and relationships between measures of psoriasis and PsA were determined. Results. Mean percentage of body surface area (BSA) affected by psoriasis was modest (12 ±17), and mean severity of erythema, induration, and scaling was moderate (4.9 ±2.1 on a 0-9 scale). Spanish Americans tended to have a higher mean percentage of BSA (18.5%) than Caucasians (11%; p = 0.067), as well as higher target lesion severity (5.55 vs 4.84; p = 0.077). Patients with psoriatic nail disease (180/221, 81%) had significantly greater number of involved distal interphalangeal (DIP) joints (p = 0.004). There were no other significant associations of skin pattern or regional involvement with PsA. Conclusion. Patients with active PsA have generally mild skin disease, and baseline relationships between psoriasis and PsA tend to be weak except for nail involvement and DIP joint activity.

Original languageEnglish (US)
Pages (from-to)1752-1756
Number of pages5
JournalJournal of Rheumatology
Volume26
Issue number8
StatePublished - 1999
Externally publishedYes

Fingerprint

Psoriatic Arthritis
Psoriasis
Body Surface Area
Nail Diseases
Erythema
Nails
Hispanic Americans
Skin Diseases
Multicenter Studies
Joints
Demography
Skin

Keywords

  • Psoriasis
  • Psoriatic arthritis
  • Seronegative arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Baseline relationships between psoriasis and psoriatic arthritis : Analysis of 221 patients with active psoriatic arthritis. / Cohen, Miriam Richter; Reda, Domenic J.; Clegg, Daniel O.

In: Journal of Rheumatology, Vol. 26, No. 8, 1999, p. 1752-1756.

Research output: Contribution to journalArticle

Cohen, Miriam Richter ; Reda, Domenic J. ; Clegg, Daniel O. / Baseline relationships between psoriasis and psoriatic arthritis : Analysis of 221 patients with active psoriatic arthritis. In: Journal of Rheumatology. 1999 ; Vol. 26, No. 8. pp. 1752-1756.
@article{b5a01098d56943a98703920b05e42a62,
title = "Baseline relationships between psoriasis and psoriatic arthritis: Analysis of 221 patients with active psoriatic arthritis",
abstract = "Objective. To determine differences in disease onset, extent, and manifestations of psoriasis among patients with active, inflammatory psoriatic arthritis (PsA), and to examine relationships that may exist between psoriasis and PsA. Methods. Baseline demographic, clinical, and laboratory data were analyzed from 221 patients enrolled in a multicenter cooperative study, and relationships between measures of psoriasis and PsA were determined. Results. Mean percentage of body surface area (BSA) affected by psoriasis was modest (12 ±17), and mean severity of erythema, induration, and scaling was moderate (4.9 ±2.1 on a 0-9 scale). Spanish Americans tended to have a higher mean percentage of BSA (18.5{\%}) than Caucasians (11{\%}; p = 0.067), as well as higher target lesion severity (5.55 vs 4.84; p = 0.077). Patients with psoriatic nail disease (180/221, 81{\%}) had significantly greater number of involved distal interphalangeal (DIP) joints (p = 0.004). There were no other significant associations of skin pattern or regional involvement with PsA. Conclusion. Patients with active PsA have generally mild skin disease, and baseline relationships between psoriasis and PsA tend to be weak except for nail involvement and DIP joint activity.",
keywords = "Psoriasis, Psoriatic arthritis, Seronegative arthritis",
author = "Cohen, {Miriam Richter} and Reda, {Domenic J.} and Clegg, {Daniel O.}",
year = "1999",
language = "English (US)",
volume = "26",
pages = "1752--1756",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "8",

}

TY - JOUR

T1 - Baseline relationships between psoriasis and psoriatic arthritis

T2 - Analysis of 221 patients with active psoriatic arthritis

AU - Cohen, Miriam Richter

AU - Reda, Domenic J.

AU - Clegg, Daniel O.

PY - 1999

Y1 - 1999

N2 - Objective. To determine differences in disease onset, extent, and manifestations of psoriasis among patients with active, inflammatory psoriatic arthritis (PsA), and to examine relationships that may exist between psoriasis and PsA. Methods. Baseline demographic, clinical, and laboratory data were analyzed from 221 patients enrolled in a multicenter cooperative study, and relationships between measures of psoriasis and PsA were determined. Results. Mean percentage of body surface area (BSA) affected by psoriasis was modest (12 ±17), and mean severity of erythema, induration, and scaling was moderate (4.9 ±2.1 on a 0-9 scale). Spanish Americans tended to have a higher mean percentage of BSA (18.5%) than Caucasians (11%; p = 0.067), as well as higher target lesion severity (5.55 vs 4.84; p = 0.077). Patients with psoriatic nail disease (180/221, 81%) had significantly greater number of involved distal interphalangeal (DIP) joints (p = 0.004). There were no other significant associations of skin pattern or regional involvement with PsA. Conclusion. Patients with active PsA have generally mild skin disease, and baseline relationships between psoriasis and PsA tend to be weak except for nail involvement and DIP joint activity.

AB - Objective. To determine differences in disease onset, extent, and manifestations of psoriasis among patients with active, inflammatory psoriatic arthritis (PsA), and to examine relationships that may exist between psoriasis and PsA. Methods. Baseline demographic, clinical, and laboratory data were analyzed from 221 patients enrolled in a multicenter cooperative study, and relationships between measures of psoriasis and PsA were determined. Results. Mean percentage of body surface area (BSA) affected by psoriasis was modest (12 ±17), and mean severity of erythema, induration, and scaling was moderate (4.9 ±2.1 on a 0-9 scale). Spanish Americans tended to have a higher mean percentage of BSA (18.5%) than Caucasians (11%; p = 0.067), as well as higher target lesion severity (5.55 vs 4.84; p = 0.077). Patients with psoriatic nail disease (180/221, 81%) had significantly greater number of involved distal interphalangeal (DIP) joints (p = 0.004). There were no other significant associations of skin pattern or regional involvement with PsA. Conclusion. Patients with active PsA have generally mild skin disease, and baseline relationships between psoriasis and PsA tend to be weak except for nail involvement and DIP joint activity.

KW - Psoriasis

KW - Psoriatic arthritis

KW - Seronegative arthritis

UR - http://www.scopus.com/inward/record.url?scp=0032770475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032770475&partnerID=8YFLogxK

M3 - Article

C2 - 10451073

AN - SCOPUS:0032770475

VL - 26

SP - 1752

EP - 1756

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 8

ER -