Baseline Plasma Zinc and Risk of First Stroke in Hypertensive Patients: A Nested Case-Control Study

Jingping Zhang, Jingjing Cao, Yuanyuan Zhang, Huan Li, Hao Zhang, Yong Huo, Jiaang Li, Xiangyi Liu, Xiaobin Wang, Xianhui Qin, Xiping Xu

Research output: Contribution to journalArticle

Abstract

Background and Purpose- We aimed to examine the relation of baseline plasma zinc with the risk of first stroke and investigate any possible effect modifiers in hypertensive patients. Methods- The study population was drawn from the CSPPT (China Stroke Primary Prevention Trial), using a nested case-control design, including 599 first stroke cases and 599 matched controls. Results- Compared with participants with baseline plasma zinc <106.9 μg/dL (median), a significantly lower risk of first hemorrhagic stroke was found in those with plasma zinc ≥106.9 μg/dL (multivariate-adjusted odds ratio, 0.45; 95% CI, 0.21-0.94). Furthermore, the inverse plasma zinc-first hemorrhagic stroke association was significantly stronger in participants with body mass index ≥25.0 kg/m2 or plasma copper <100.1 μg/dL at baseline (Pinteraction <0.05 for both variables). However, there was no significant association between plasma zinc and first ischemic stroke (<103.3 versus ≥103.3 μg/dL [median]; multivariate-adjusted odds ratio, 1.16; 95% CI, 0.83-1.61). Conclusions- In this sample of hypertensive patients, we found a significant, inverse association between plasma zinc and first hemorrhagic stroke. Clinical Trial Registration- URL: https://www.clinicaltrials.gov. Unique identifier: NCT00794885.

Original languageEnglish (US)
Pages (from-to)3255-3258
Number of pages4
JournalStroke
Volume50
Issue number11
DOIs
StatePublished - Nov 1 2019

Keywords

  • body mass index
  • copper
  • first stroke
  • hypertension
  • zinc

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Zhang, J., Cao, J., Zhang, Y., Li, H., Zhang, H., Huo, Y., Li, J., Liu, X., Wang, X., Qin, X., & Xu, X. (2019). Baseline Plasma Zinc and Risk of First Stroke in Hypertensive Patients: A Nested Case-Control Study. Stroke, 50(11), 3255-3258. https://doi.org/10.1161/STROKEAHA.119.027003