Baseline MRI associates with later naming status in primary progressive aphasia

Andreia V. Faria, Aaron Meyer, Rhonda Friedman, Donna C. Tippett, Argye E. Hillis

Research output: Contribution to journalArticle

Abstract

Advanced imaging studies in neurodegenerative disease have yielded new insights into subtypes of disease, progression of disease in various brain regions, and changes in structural and functional connectivity between brain regions related to symptom progression. However, few studies have revealed imaging markers at baseline that correlate with rate or degree of decline in function. Here we tested the hypothesis that imaging features at baseline correlate with outcome of naming in primary progressive aphasia. We obtained longitudinal multimodal imaging in 15 individuals with primary progressive aphasia at the same time points as assessment of naming. We found that functional connectivity between particular brain regions (measured with resting state functional connectivity magnetic resonance imaging) is strongly associated with accuracy of naming 21 months later, independently of baseline severity of naming impairment. These data indicate that functional connectivity may carry information about later performance in naming, and is potentially useful for refining prognosis.

Original languageEnglish (US)
Article number104723
JournalBrain and Language
Volume201
DOIs
StatePublished - Feb 2020

Fingerprint

Primary Progressive Aphasia
speech disorder
brain
Disease
Brain
Multimodal Imaging
Neurodegenerative Diseases
Disease Progression
Magnetic Resonance Imaging
performance
Associates
Naming
Connectivity
Imaging

ASJC Scopus subject areas

  • Language and Linguistics
  • Experimental and Cognitive Psychology
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

Cite this

Baseline MRI associates with later naming status in primary progressive aphasia. / Faria, Andreia V.; Meyer, Aaron; Friedman, Rhonda; Tippett, Donna C.; Hillis, Argye E.

In: Brain and Language, Vol. 201, 104723, 02.2020.

Research output: Contribution to journalArticle

@article{33e1661ae0ce41ff9b13ff82e86a9205,
title = "Baseline MRI associates with later naming status in primary progressive aphasia",
abstract = "Advanced imaging studies in neurodegenerative disease have yielded new insights into subtypes of disease, progression of disease in various brain regions, and changes in structural and functional connectivity between brain regions related to symptom progression. However, few studies have revealed imaging markers at baseline that correlate with rate or degree of decline in function. Here we tested the hypothesis that imaging features at baseline correlate with outcome of naming in primary progressive aphasia. We obtained longitudinal multimodal imaging in 15 individuals with primary progressive aphasia at the same time points as assessment of naming. We found that functional connectivity between particular brain regions (measured with resting state functional connectivity magnetic resonance imaging) is strongly associated with accuracy of naming 21 months later, independently of baseline severity of naming impairment. These data indicate that functional connectivity may carry information about later performance in naming, and is potentially useful for refining prognosis.",
author = "Faria, {Andreia V.} and Aaron Meyer and Rhonda Friedman and Tippett, {Donna C.} and Hillis, {Argye E.}",
year = "2020",
month = "2",
doi = "10.1016/j.bandl.2019.104723",
language = "English (US)",
volume = "201",
journal = "Brain and Language",
issn = "0093-934X",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Baseline MRI associates with later naming status in primary progressive aphasia

AU - Faria, Andreia V.

AU - Meyer, Aaron

AU - Friedman, Rhonda

AU - Tippett, Donna C.

AU - Hillis, Argye E.

PY - 2020/2

Y1 - 2020/2

N2 - Advanced imaging studies in neurodegenerative disease have yielded new insights into subtypes of disease, progression of disease in various brain regions, and changes in structural and functional connectivity between brain regions related to symptom progression. However, few studies have revealed imaging markers at baseline that correlate with rate or degree of decline in function. Here we tested the hypothesis that imaging features at baseline correlate with outcome of naming in primary progressive aphasia. We obtained longitudinal multimodal imaging in 15 individuals with primary progressive aphasia at the same time points as assessment of naming. We found that functional connectivity between particular brain regions (measured with resting state functional connectivity magnetic resonance imaging) is strongly associated with accuracy of naming 21 months later, independently of baseline severity of naming impairment. These data indicate that functional connectivity may carry information about later performance in naming, and is potentially useful for refining prognosis.

AB - Advanced imaging studies in neurodegenerative disease have yielded new insights into subtypes of disease, progression of disease in various brain regions, and changes in structural and functional connectivity between brain regions related to symptom progression. However, few studies have revealed imaging markers at baseline that correlate with rate or degree of decline in function. Here we tested the hypothesis that imaging features at baseline correlate with outcome of naming in primary progressive aphasia. We obtained longitudinal multimodal imaging in 15 individuals with primary progressive aphasia at the same time points as assessment of naming. We found that functional connectivity between particular brain regions (measured with resting state functional connectivity magnetic resonance imaging) is strongly associated with accuracy of naming 21 months later, independently of baseline severity of naming impairment. These data indicate that functional connectivity may carry information about later performance in naming, and is potentially useful for refining prognosis.

UR - http://www.scopus.com/inward/record.url?scp=85077936592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077936592&partnerID=8YFLogxK

U2 - 10.1016/j.bandl.2019.104723

DO - 10.1016/j.bandl.2019.104723

M3 - Article

C2 - 31864209

AN - SCOPUS:85077936592

VL - 201

JO - Brain and Language

JF - Brain and Language

SN - 0093-934X

M1 - 104723

ER -