Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer

Miriam N. Lango, Brian Egleston, Carolyn Fang, Barbara Burtness, Thomas Galloway, Jeffrey Liu, Ranee Mehra, Barbara Ebersole, Kathleen Moran, John A. Ridge

Research output: Contribution to journalArticle

Abstract

BACKGROUND In head and neck cancer patients prior to treatment, dysphagia noted by patients is more common than aspiration on formal swallow studies. The authors hypothesized that patient-reported dysphagia impacts multiple domains of quality of life (QOL) and predicts disease recurrence and disease-related death. METHODS The Swal-QOL, a dysphagia-specific, swallowing-related, QOL measure, and the EuroQOL-5D-3L were administered to 159 patients before treatment with curative intent in this prospective cohort study. Logistic regression analysis evaluated associations among clinical and subjective measures. Multivariable competing risk regression tested the impact of clinical, tumor, and patient-reported measures on survival. RESULTS Baseline dysphagia, pain, and diminished patient-reported health state were found to be closely associated with weight loss before treatment and advanced T classification. However, only 58% of patients (23 of 40 patients) reporting dysphagia experienced > 5% weight loss. Dysphagia was found to be associated with pain and/or diminished patient-reported health state, independent of weight loss. Female patients were more likely to report pain and dysphagia, whereas male patients reported dysphagia alone. Dysphagia was found to be predictive of disease recurrence and disease-related death, adjusting for T and N classifications, ECOG performance status, smoking status, and weight loss, and accounting for competing risks of death (recurrence-free survival: hazards ratio, 3.8 [95% confidence interval, 1.7-8.4; P =.001] and disease-related death: hazards ratio, 4.2 [95% confidence interval, 1.04-5; P =.004]). CONCLUSIONS Baseline dysphagia affects multiple domains of QOL and general health perceptions in patients with head and neck cancer prior to treatment. A dysphagia measure captures the effort of maintaining nutrition, and identifies patients predisposed to disease recurrence and disease-related death. Cancer 2014;120:840-847.

Original languageEnglish (US)
Pages (from-to)840-847
Number of pages8
JournalCancer
Volume120
Issue number6
DOIs
StatePublished - Mar 15 2014
Externally publishedYes

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Head and Neck Neoplasms
Deglutition Disorders
Survival
Health
Weight Loss
Quality of Life
Recurrence
Deglutition
Pain
Confidence Intervals
Therapeutics
Neoplasms
Cohort Studies
Logistic Models
Smoking
Regression Analysis
Prospective Studies

Keywords

  • baseline weight loss
  • dysphagia
  • head and neck cancer
  • health perceptions
  • survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lango, M. N., Egleston, B., Fang, C., Burtness, B., Galloway, T., Liu, J., ... Ridge, J. A. (2014). Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer. Cancer, 120(6), 840-847. https://doi.org/10.1002/cncr.28482

Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer. / Lango, Miriam N.; Egleston, Brian; Fang, Carolyn; Burtness, Barbara; Galloway, Thomas; Liu, Jeffrey; Mehra, Ranee; Ebersole, Barbara; Moran, Kathleen; Ridge, John A.

In: Cancer, Vol. 120, No. 6, 15.03.2014, p. 840-847.

Research output: Contribution to journalArticle

Lango, MN, Egleston, B, Fang, C, Burtness, B, Galloway, T, Liu, J, Mehra, R, Ebersole, B, Moran, K & Ridge, JA 2014, 'Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer', Cancer, vol. 120, no. 6, pp. 840-847. https://doi.org/10.1002/cncr.28482
Lango MN, Egleston B, Fang C, Burtness B, Galloway T, Liu J et al. Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer. Cancer. 2014 Mar 15;120(6):840-847. https://doi.org/10.1002/cncr.28482
Lango, Miriam N. ; Egleston, Brian ; Fang, Carolyn ; Burtness, Barbara ; Galloway, Thomas ; Liu, Jeffrey ; Mehra, Ranee ; Ebersole, Barbara ; Moran, Kathleen ; Ridge, John A. / Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer. In: Cancer. 2014 ; Vol. 120, No. 6. pp. 840-847.
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abstract = "BACKGROUND In head and neck cancer patients prior to treatment, dysphagia noted by patients is more common than aspiration on formal swallow studies. The authors hypothesized that patient-reported dysphagia impacts multiple domains of quality of life (QOL) and predicts disease recurrence and disease-related death. METHODS The Swal-QOL, a dysphagia-specific, swallowing-related, QOL measure, and the EuroQOL-5D-3L were administered to 159 patients before treatment with curative intent in this prospective cohort study. Logistic regression analysis evaluated associations among clinical and subjective measures. Multivariable competing risk regression tested the impact of clinical, tumor, and patient-reported measures on survival. RESULTS Baseline dysphagia, pain, and diminished patient-reported health state were found to be closely associated with weight loss before treatment and advanced T classification. However, only 58{\%} of patients (23 of 40 patients) reporting dysphagia experienced > 5{\%} weight loss. Dysphagia was found to be associated with pain and/or diminished patient-reported health state, independent of weight loss. Female patients were more likely to report pain and dysphagia, whereas male patients reported dysphagia alone. Dysphagia was found to be predictive of disease recurrence and disease-related death, adjusting for T and N classifications, ECOG performance status, smoking status, and weight loss, and accounting for competing risks of death (recurrence-free survival: hazards ratio, 3.8 [95{\%} confidence interval, 1.7-8.4; P =.001] and disease-related death: hazards ratio, 4.2 [95{\%} confidence interval, 1.04-5; P =.004]). CONCLUSIONS Baseline dysphagia affects multiple domains of QOL and general health perceptions in patients with head and neck cancer prior to treatment. A dysphagia measure captures the effort of maintaining nutrition, and identifies patients predisposed to disease recurrence and disease-related death. Cancer 2014;120:840-847.",
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AU - Fang, Carolyn

AU - Burtness, Barbara

AU - Galloway, Thomas

AU - Liu, Jeffrey

AU - Mehra, Ranee

AU - Ebersole, Barbara

AU - Moran, Kathleen

AU - Ridge, John A.

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N2 - BACKGROUND In head and neck cancer patients prior to treatment, dysphagia noted by patients is more common than aspiration on formal swallow studies. The authors hypothesized that patient-reported dysphagia impacts multiple domains of quality of life (QOL) and predicts disease recurrence and disease-related death. METHODS The Swal-QOL, a dysphagia-specific, swallowing-related, QOL measure, and the EuroQOL-5D-3L were administered to 159 patients before treatment with curative intent in this prospective cohort study. Logistic regression analysis evaluated associations among clinical and subjective measures. Multivariable competing risk regression tested the impact of clinical, tumor, and patient-reported measures on survival. RESULTS Baseline dysphagia, pain, and diminished patient-reported health state were found to be closely associated with weight loss before treatment and advanced T classification. However, only 58% of patients (23 of 40 patients) reporting dysphagia experienced > 5% weight loss. Dysphagia was found to be associated with pain and/or diminished patient-reported health state, independent of weight loss. Female patients were more likely to report pain and dysphagia, whereas male patients reported dysphagia alone. Dysphagia was found to be predictive of disease recurrence and disease-related death, adjusting for T and N classifications, ECOG performance status, smoking status, and weight loss, and accounting for competing risks of death (recurrence-free survival: hazards ratio, 3.8 [95% confidence interval, 1.7-8.4; P =.001] and disease-related death: hazards ratio, 4.2 [95% confidence interval, 1.04-5; P =.004]). CONCLUSIONS Baseline dysphagia affects multiple domains of QOL and general health perceptions in patients with head and neck cancer prior to treatment. A dysphagia measure captures the effort of maintaining nutrition, and identifies patients predisposed to disease recurrence and disease-related death. Cancer 2014;120:840-847.

AB - BACKGROUND In head and neck cancer patients prior to treatment, dysphagia noted by patients is more common than aspiration on formal swallow studies. The authors hypothesized that patient-reported dysphagia impacts multiple domains of quality of life (QOL) and predicts disease recurrence and disease-related death. METHODS The Swal-QOL, a dysphagia-specific, swallowing-related, QOL measure, and the EuroQOL-5D-3L were administered to 159 patients before treatment with curative intent in this prospective cohort study. Logistic regression analysis evaluated associations among clinical and subjective measures. Multivariable competing risk regression tested the impact of clinical, tumor, and patient-reported measures on survival. RESULTS Baseline dysphagia, pain, and diminished patient-reported health state were found to be closely associated with weight loss before treatment and advanced T classification. However, only 58% of patients (23 of 40 patients) reporting dysphagia experienced > 5% weight loss. Dysphagia was found to be associated with pain and/or diminished patient-reported health state, independent of weight loss. Female patients were more likely to report pain and dysphagia, whereas male patients reported dysphagia alone. Dysphagia was found to be predictive of disease recurrence and disease-related death, adjusting for T and N classifications, ECOG performance status, smoking status, and weight loss, and accounting for competing risks of death (recurrence-free survival: hazards ratio, 3.8 [95% confidence interval, 1.7-8.4; P =.001] and disease-related death: hazards ratio, 4.2 [95% confidence interval, 1.04-5; P =.004]). CONCLUSIONS Baseline dysphagia affects multiple domains of QOL and general health perceptions in patients with head and neck cancer prior to treatment. A dysphagia measure captures the effort of maintaining nutrition, and identifies patients predisposed to disease recurrence and disease-related death. Cancer 2014;120:840-847.

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