Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy

Van Khue Ton; Aditya Bhonsale; Nisha A. Gilotra; Marc K. Halushka; Charles Steenbergen; Johana Almansa; Emily Brown; Ryan Tedford; Ilan Wittstein; Kavita Sharma; Stuart Russell; Daniel P. Judge

doi:10.1016/j.cardfail.2016.12.006

Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy

Van Khue Ton, Aditya Bhonsale, Nisha A. Gilotra, Marc K. Halushka, Charles Steenbergen, Johana Almansa, Emily Brown, Ryan Tedford, Ilan Wittstein, Kavita Sharma, Stuart Russell, Daniel P. Judge

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Recent studies have suggested a high prevalence of cardiac amyloidosis (CAm) in heart failure (HF) patients. CAm might be underdiagnosed owing to low clinical suspicion. Methods and Results: We performed retrospective analysis of 259 patients with HF and ejection fraction (EF) ≥50% referred for endomyocardial biopsy. Seventy-three (28%) had CAm. Multivariable independent predictors of CAm were identified. Over a mean follow-up of 2.6 ± 3.3 years, CAm patients had worse survival than those without (1.5 y vs 6.3 y; log rank P < .0001). Conclusions: Clinicians should be suspicious of CAm in patients with EF 50%-75%, >50 years of age, BMI <30 kg/m², peripheral neuropathy, Sokolow-Lyon index ≤15 mm, and septal wall thickness ≥1.4 cm.

Original language	English (US)
Journal	Journal of Cardiac Failure
DOIs	https://doi.org/10.1016/j.cardfail.2016.12.006
State	Accepted/In press - Mar 7 2016

Keywords

Cardiac amyloid
Heart failure
Predictors

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.cardfail.2016.12.006

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@article{b2cceab4c1704307b16ace8c69fbf11c,

title = "Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy",

abstract = "Background: Recent studies have suggested a high prevalence of cardiac amyloidosis (CAm) in heart failure (HF) patients. CAm might be underdiagnosed owing to low clinical suspicion. Methods and Results: We performed retrospective analysis of 259 patients with HF and ejection fraction (EF) ≥50% referred for endomyocardial biopsy. Seventy-three (28%) had CAm. Multivariable independent predictors of CAm were identified. Over a mean follow-up of 2.6 ± 3.3 years, CAm patients had worse survival than those without (1.5 y vs 6.3 y; log rank P < .0001). Conclusions: Clinicians should be suspicious of CAm in patients with EF 50%-75%, >50 years of age, BMI <30 kg/m2, peripheral neuropathy, Sokolow-Lyon index ≤15 mm, and septal wall thickness ≥1.4 cm.",

keywords = "Cardiac amyloid, Heart failure, Predictors",

author = "Ton, {Van Khue} and Aditya Bhonsale and Gilotra, {Nisha A.} and Halushka, {Marc K.} and Charles Steenbergen and Johana Almansa and Emily Brown and Ryan Tedford and Ilan Wittstein and Kavita Sharma and Stuart Russell and Judge, {Daniel P.}",

year = "2016",

month = mar,

day = "7",

doi = "10.1016/j.cardfail.2016.12.006",

language = "English (US)",

journal = "Journal of Cardiac Failure",

issn = "1071-9164",

publisher = "Churchill Livingstone",

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TY - JOUR

T1 - Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy

AU - Ton, Van Khue

AU - Bhonsale, Aditya

AU - Gilotra, Nisha A.

AU - Halushka, Marc K.

AU - Steenbergen, Charles

AU - Almansa, Johana

AU - Brown, Emily

AU - Tedford, Ryan

AU - Wittstein, Ilan

AU - Sharma, Kavita

AU - Russell, Stuart

AU - Judge, Daniel P.

PY - 2016/3/7

Y1 - 2016/3/7

N2 - Background: Recent studies have suggested a high prevalence of cardiac amyloidosis (CAm) in heart failure (HF) patients. CAm might be underdiagnosed owing to low clinical suspicion. Methods and Results: We performed retrospective analysis of 259 patients with HF and ejection fraction (EF) ≥50% referred for endomyocardial biopsy. Seventy-three (28%) had CAm. Multivariable independent predictors of CAm were identified. Over a mean follow-up of 2.6 ± 3.3 years, CAm patients had worse survival than those without (1.5 y vs 6.3 y; log rank P < .0001). Conclusions: Clinicians should be suspicious of CAm in patients with EF 50%-75%, >50 years of age, BMI <30 kg/m2, peripheral neuropathy, Sokolow-Lyon index ≤15 mm, and septal wall thickness ≥1.4 cm.

AB - Background: Recent studies have suggested a high prevalence of cardiac amyloidosis (CAm) in heart failure (HF) patients. CAm might be underdiagnosed owing to low clinical suspicion. Methods and Results: We performed retrospective analysis of 259 patients with HF and ejection fraction (EF) ≥50% referred for endomyocardial biopsy. Seventy-three (28%) had CAm. Multivariable independent predictors of CAm were identified. Over a mean follow-up of 2.6 ± 3.3 years, CAm patients had worse survival than those without (1.5 y vs 6.3 y; log rank P < .0001). Conclusions: Clinicians should be suspicious of CAm in patients with EF 50%-75%, >50 years of age, BMI <30 kg/m2, peripheral neuropathy, Sokolow-Lyon index ≤15 mm, and septal wall thickness ≥1.4 cm.

KW - Cardiac amyloid

KW - Heart failure

KW - Predictors

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DO - 10.1016/j.cardfail.2016.12.006

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AN - SCOPUS:85008514561

SN - 1071-9164

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

ER -

Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy

Abstract

Keywords

ASJC Scopus subject areas

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