Baseline cardiovascular risk predicts subsequent changes in resting brain function

Lori L. Beason-Held, Madhav Thambisetty, Gerard Deib, Jitka Sojkova, Bennett A. Landman, Alan B. Zonderman, Luigi Ferrucci, Michael A Kraut, Susan M. Resnick

Research output: Contribution to journalArticle

Abstract

Background and Purpose-: The Framingham Heart Study group cardiovascular disease risk profile (FCRP) score was used to assess the relationship between baseline cardiovascular risk and subsequent changes in resting state cerebral blood flow (CBF) in cognitively normal older participants from the Baltimore Longitudinal Study of Aging. Methods-: Ninty-seven cognitively normal participants underwent annual resting-state positron emission tomography scans at baseline and over a period of up to 8 years (mean interval, 7.4 years). Images quantifying voxel-wise longitudinal rates of CBF change were calculated and used to examine the relationship between baseline FCRP score and changes over time in regional CBF. Individual components of the FCRP score (age, cholesterol, blood pressure, smoking status, and type 2 diabetes) were also correlated with changes in regional CBF to examine the independent contributions of each component to the overall pattern of change. Results-: Higher baseline FCRP scores were associated with accelerated longitudinal decline in CBF in orbitofrontal, medial frontal/anterior cingulate, insular, precuneus, and brain stem regions. Of the components that comprise the FCRP score, higher diastolic blood pressure and diabetes were associated independently with greater decline in the medial frontal/anterior cingulate and insular regions, respectively. Conclusions-: Baseline cardiovascular risk factors are associated with greater rates of decline in resting state regional brain function. The regions showing accelerated decline participate in higher-order cognitive processes and are also vulnerable to age-related neuropathology. These Results, in conjunction with other studies, encourage early treatment of cardiovascular risk factors in older individuals.

Original languageEnglish (US)
Pages (from-to)1542-1547
Number of pages6
JournalStroke
Volume43
Issue number6
DOIs
StatePublished - Jun 2012

Fingerprint

Cerebrovascular Circulation
Gyrus Cinguli
Brain
Regional Blood Flow
Blood Pressure
Baltimore
Parietal Lobe
Positron-Emission Tomography
Type 2 Diabetes Mellitus
Brain Stem
Longitudinal Studies
Cardiovascular Diseases
Smoking
Cholesterol
Hypertension

Keywords

  • aging
  • cholesterol
  • diabetes
  • hypertension
  • positron emission tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Beason-Held, L. L., Thambisetty, M., Deib, G., Sojkova, J., Landman, B. A., Zonderman, A. B., ... Resnick, S. M. (2012). Baseline cardiovascular risk predicts subsequent changes in resting brain function. Stroke, 43(6), 1542-1547. https://doi.org/10.1161/STROKEAHA.111.638437

Baseline cardiovascular risk predicts subsequent changes in resting brain function. / Beason-Held, Lori L.; Thambisetty, Madhav; Deib, Gerard; Sojkova, Jitka; Landman, Bennett A.; Zonderman, Alan B.; Ferrucci, Luigi; Kraut, Michael A; Resnick, Susan M.

In: Stroke, Vol. 43, No. 6, 06.2012, p. 1542-1547.

Research output: Contribution to journalArticle

Beason-Held, LL, Thambisetty, M, Deib, G, Sojkova, J, Landman, BA, Zonderman, AB, Ferrucci, L, Kraut, MA & Resnick, SM 2012, 'Baseline cardiovascular risk predicts subsequent changes in resting brain function', Stroke, vol. 43, no. 6, pp. 1542-1547. https://doi.org/10.1161/STROKEAHA.111.638437
Beason-Held LL, Thambisetty M, Deib G, Sojkova J, Landman BA, Zonderman AB et al. Baseline cardiovascular risk predicts subsequent changes in resting brain function. Stroke. 2012 Jun;43(6):1542-1547. https://doi.org/10.1161/STROKEAHA.111.638437
Beason-Held, Lori L. ; Thambisetty, Madhav ; Deib, Gerard ; Sojkova, Jitka ; Landman, Bennett A. ; Zonderman, Alan B. ; Ferrucci, Luigi ; Kraut, Michael A ; Resnick, Susan M. / Baseline cardiovascular risk predicts subsequent changes in resting brain function. In: Stroke. 2012 ; Vol. 43, No. 6. pp. 1542-1547.
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