TY - JOUR
T1 - Baseline cardiovascular risk predicts subsequent changes in resting brain function
AU - Beason-Held, Lori L.
AU - Thambisetty, Madhav
AU - Deib, Gerard
AU - Sojkova, Jitka
AU - Landman, Bennett A.
AU - Zonderman, Alan B.
AU - Ferrucci, Luigi
AU - Kraut, Michael A.
AU - Resnick, Susan M.
PY - 2012/6
Y1 - 2012/6
N2 - Background and Purpose-: The Framingham Heart Study group cardiovascular disease risk profile (FCRP) score was used to assess the relationship between baseline cardiovascular risk and subsequent changes in resting state cerebral blood flow (CBF) in cognitively normal older participants from the Baltimore Longitudinal Study of Aging. Methods-: Ninty-seven cognitively normal participants underwent annual resting-state positron emission tomography scans at baseline and over a period of up to 8 years (mean interval, 7.4 years). Images quantifying voxel-wise longitudinal rates of CBF change were calculated and used to examine the relationship between baseline FCRP score and changes over time in regional CBF. Individual components of the FCRP score (age, cholesterol, blood pressure, smoking status, and type 2 diabetes) were also correlated with changes in regional CBF to examine the independent contributions of each component to the overall pattern of change. Results-: Higher baseline FCRP scores were associated with accelerated longitudinal decline in CBF in orbitofrontal, medial frontal/anterior cingulate, insular, precuneus, and brain stem regions. Of the components that comprise the FCRP score, higher diastolic blood pressure and diabetes were associated independently with greater decline in the medial frontal/anterior cingulate and insular regions, respectively. Conclusions-: Baseline cardiovascular risk factors are associated with greater rates of decline in resting state regional brain function. The regions showing accelerated decline participate in higher-order cognitive processes and are also vulnerable to age-related neuropathology. These Results, in conjunction with other studies, encourage early treatment of cardiovascular risk factors in older individuals.
AB - Background and Purpose-: The Framingham Heart Study group cardiovascular disease risk profile (FCRP) score was used to assess the relationship between baseline cardiovascular risk and subsequent changes in resting state cerebral blood flow (CBF) in cognitively normal older participants from the Baltimore Longitudinal Study of Aging. Methods-: Ninty-seven cognitively normal participants underwent annual resting-state positron emission tomography scans at baseline and over a period of up to 8 years (mean interval, 7.4 years). Images quantifying voxel-wise longitudinal rates of CBF change were calculated and used to examine the relationship between baseline FCRP score and changes over time in regional CBF. Individual components of the FCRP score (age, cholesterol, blood pressure, smoking status, and type 2 diabetes) were also correlated with changes in regional CBF to examine the independent contributions of each component to the overall pattern of change. Results-: Higher baseline FCRP scores were associated with accelerated longitudinal decline in CBF in orbitofrontal, medial frontal/anterior cingulate, insular, precuneus, and brain stem regions. Of the components that comprise the FCRP score, higher diastolic blood pressure and diabetes were associated independently with greater decline in the medial frontal/anterior cingulate and insular regions, respectively. Conclusions-: Baseline cardiovascular risk factors are associated with greater rates of decline in resting state regional brain function. The regions showing accelerated decline participate in higher-order cognitive processes and are also vulnerable to age-related neuropathology. These Results, in conjunction with other studies, encourage early treatment of cardiovascular risk factors in older individuals.
KW - aging
KW - cholesterol
KW - diabetes
KW - hypertension
KW - positron emission tomography
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U2 - 10.1161/STROKEAHA.111.638437
DO - 10.1161/STROKEAHA.111.638437
M3 - Article
C2 - 22492519
AN - SCOPUS:84861607315
SN - 0039-2499
VL - 43
SP - 1542
EP - 1547
JO - Stroke
JF - Stroke
IS - 6
ER -