TY - JOUR
T1 - Baseline and postoperative levels of C-reactive protein and interleukins as inflammatory predictors of atrial fibrillation following cardiac surgery
T2 - A systematic review and meta-analysis
AU - Weymann, Alexander
AU - Popov, Aron Frederik
AU - Sabashnikov, Anton
AU - Ali-Hasan-Al-Saegh, Sadeq
AU - Ryazanov, Mikhail
AU - Tse, Gary
AU - Mirhosseini, Seyed Jalil
AU - Liu, Tong
AU - Lotfaliani, Mohammadreza
AU - Sedaghat, Meghdad
AU - Baker, William L.
AU - Ghanei, Azam
AU - Yavuz, Senol
AU - Zeriouh, Mohamed
AU - Izadpanah, Payman
AU - Dehghan, Hamidreza
AU - Testa, Luca
AU - Nikfard, Maryam
AU - De Oliveira Sá, Michel Pompeu Barros
AU - Mashhour, Ahmed
AU - Nombela-Franco, Luis
AU - Rezaeisadrabadi, Mohammad
AU - D'Ascenzo, Fabrizio
AU - Zhigalov, Konstantin
AU - Benedetto, Umberto
AU - Najafi, Soroosh Aminolsharieh
AU - Szczechowicz, Marcin
AU - Roever, Leonardo
AU - Meng, Lei
AU - Gong, Mengqi
AU - Deshmukh, Abhishek J.
AU - Palmerini, Tullio
AU - Linde, Cecilia
AU - Filipiak, Krzysztof J.
AU - Stone, Gregg W.
AU - Biondi-Zoccai, Giuseppe
AU - Calkins, Hugh
N1 - Publisher Copyright:
© Copyright 2018 Polskie Towarzystwo Kardiologiczne.
PY - 2018/2/16
Y1 - 2018/2/16
N2 - Background: Postoperative atrial fibrillation (POAF) is a leading arrhythmia with high incidence and serious clinical implications after cardiac surgery. Cardiac surgery is associated with systemic inflammatory response including increase in cytokines and activation of endothelial and leukocyte responses. Aim This systematic review and meta-analysis aimed to determine the strength of evidence for evaluating the association of inflammatory markers, such as C-reactive protein (CRP) and interleukins (IL), with POAF following isolated coronary artery bypass grafting (CABG), isolated valvular surgery, or a combination of these procedures. Methods: We conducted a meta-analysis of studies evaluating measured baseline (from one week before surgical procedures) and postoperative levels (until one week after surgical procedures) of inflammatory markers in patients with POAF. A comprehensive search was performed in electronic medical databases (Medline/PubMed, Web of Science, Embase, Science Direct, and Google Scholar) from their inception through May 2017 to identify relevant studies. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results: A literature search of all major databases retrieved 1014 studies. After screening, 42 studies were analysed including a total of 8398 patients. Pooled analysis showed baseline levels of CRP (standard mean difference [SMD] 0.457 mg/L, p < 0.001), baseline levels of IL-6 (SMD 0.398 pg/mL, p < 0.001), postoperative levels of CRP (SMD 0.576 mg/L, p < 0.001), postoperative levels of IL-6 (SMD 1.66 pg/mL, p < 0.001), postoperative levels of IL-8 (SMD 0.839 pg/mL, p < 0.001), and postoperative levels of IL-10 (SMD 0.590 pg/mL, p < 0.001) to be relevant inflammatory parameters significantly associated with POAF. Conclusions: Perioperative inflammation is proposed to be involved in the pathogenesis of POAF. Therefore, perioperative assessment of CRP, IL-6, IL-8, and IL-10 can help clinicians in terms of predicting and monitoring for POAF.
AB - Background: Postoperative atrial fibrillation (POAF) is a leading arrhythmia with high incidence and serious clinical implications after cardiac surgery. Cardiac surgery is associated with systemic inflammatory response including increase in cytokines and activation of endothelial and leukocyte responses. Aim This systematic review and meta-analysis aimed to determine the strength of evidence for evaluating the association of inflammatory markers, such as C-reactive protein (CRP) and interleukins (IL), with POAF following isolated coronary artery bypass grafting (CABG), isolated valvular surgery, or a combination of these procedures. Methods: We conducted a meta-analysis of studies evaluating measured baseline (from one week before surgical procedures) and postoperative levels (until one week after surgical procedures) of inflammatory markers in patients with POAF. A comprehensive search was performed in electronic medical databases (Medline/PubMed, Web of Science, Embase, Science Direct, and Google Scholar) from their inception through May 2017 to identify relevant studies. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results: A literature search of all major databases retrieved 1014 studies. After screening, 42 studies were analysed including a total of 8398 patients. Pooled analysis showed baseline levels of CRP (standard mean difference [SMD] 0.457 mg/L, p < 0.001), baseline levels of IL-6 (SMD 0.398 pg/mL, p < 0.001), postoperative levels of CRP (SMD 0.576 mg/L, p < 0.001), postoperative levels of IL-6 (SMD 1.66 pg/mL, p < 0.001), postoperative levels of IL-8 (SMD 0.839 pg/mL, p < 0.001), and postoperative levels of IL-10 (SMD 0.590 pg/mL, p < 0.001) to be relevant inflammatory parameters significantly associated with POAF. Conclusions: Perioperative inflammation is proposed to be involved in the pathogenesis of POAF. Therefore, perioperative assessment of CRP, IL-6, IL-8, and IL-10 can help clinicians in terms of predicting and monitoring for POAF.
KW - Atrial fibrillation
KW - C-reactive protein
KW - Cytokines
KW - Inflammation
KW - Interleukins
KW - Meta-analysis
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=85042111423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042111423&partnerID=8YFLogxK
U2 - 10.5603/KP.a2017.0242
DO - 10.5603/KP.a2017.0242
M3 - Article
C2 - 29354906
AN - SCOPUS:85042111423
SN - 0022-9032
VL - 76
SP - 440
EP - 451
JO - Kardiologia Polska
JF - Kardiologia Polska
IS - 2
ER -