TY - JOUR
T1 - Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder
AU - Aylward, Elizabeth H.
AU - Roberts-Twillie, Joy V.
AU - Barta, Patrick E.
AU - Kumar, Ashok J.
AU - Harris, Gordon J.
AU - Geer, Michael
AU - Peyser, Carol E.
AU - Pearlson, Godfrey D.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1994/5
Y1 - 1994/5
N2 - Objective: Accumulating evidence suggests an association between abnormalities of the basal ganglia and affective disorders. The authors hypothesized that patients with bipolar disorder would demonstrate smaller basal ganglia volumes and a greater number of hyperintensities on magnetic resonance imaging than comparison subjects who were matched on age, race, sex, and education. Method: Volumes of the caudate, putamen, and globus pallidus were measured in 30 patients with bipolar disorder and 30 matched normal comparison subjects. The presence, number, and location of hyperintensities were also assessed. Results: Male patients with bipolar disorder demonstrated larger caudate volumes than male comparison subjects. Older, but not younger, patients with bipolar disorder demonstrated more hyperintensities than comparison subjects, primarily in frontal lobe white matter. Conclusions: These results are not consistent with those of previous studies showing reduced basal ganglia volume in subjects with affective disorders, but they are consistent with previous findings of increased white matter hyperintensities, especially in older patients with bipolar disorder. Considered together with results from other studies, the findings suggest that the nature of basal ganglia/subcortical white matter involvement may differ according to the type of depression (unipolar versus bipolar) and the age and sex of the patient.
AB - Objective: Accumulating evidence suggests an association between abnormalities of the basal ganglia and affective disorders. The authors hypothesized that patients with bipolar disorder would demonstrate smaller basal ganglia volumes and a greater number of hyperintensities on magnetic resonance imaging than comparison subjects who were matched on age, race, sex, and education. Method: Volumes of the caudate, putamen, and globus pallidus were measured in 30 patients with bipolar disorder and 30 matched normal comparison subjects. The presence, number, and location of hyperintensities were also assessed. Results: Male patients with bipolar disorder demonstrated larger caudate volumes than male comparison subjects. Older, but not younger, patients with bipolar disorder demonstrated more hyperintensities than comparison subjects, primarily in frontal lobe white matter. Conclusions: These results are not consistent with those of previous studies showing reduced basal ganglia volume in subjects with affective disorders, but they are consistent with previous findings of increased white matter hyperintensities, especially in older patients with bipolar disorder. Considered together with results from other studies, the findings suggest that the nature of basal ganglia/subcortical white matter involvement may differ according to the type of depression (unipolar versus bipolar) and the age and sex of the patient.
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U2 - 10.1176/ajp.151.5.687
DO - 10.1176/ajp.151.5.687
M3 - Article
C2 - 8166310
AN - SCOPUS:0028207989
SN - 0002-953X
VL - 151
SP - 687
EP - 693
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 5
ER -