Basal ganglia iron in tardive dyskinesia: an MRI study

Ahmed M. Elkashef, Michael F. Egan, Joseph A. Frank, Thomas M. Hyde, Bobbie K. Lewis, Richard Jed Wyatt

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Alterations in brain iron could play an important role in the development of tardive dyskinesia in patients receiving neuroleptic medication. To test this hypothesis, magnetic resonance imaging scans of the brain were performed on 21 chronic schizophrenic patients. Ten patients met research diagnostic criteria for persistent tardive dyskinesia, and 11 were free of tardive dyskinesia. All patients had received long-term neuroleptic treatment and wre on a stable neuroleptic dose for at least 3 months before scanning. The signal intensity of basal ganglia structures was obtained as a quantitative estimate of brain iron content. No difference was found in the signal intensity ratios between the two groups. This suggests that iron deposition in the basal ganglia, at least as assessed by this measure, does not play a role in the pathophysiology of tardive dyskinesia.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalBiological psychiatry
Issue number1
StatePublished - Jan 1 1994
Externally publishedYes


  • Basal ganglia
  • MRI
  • iron
  • tardive dyskinesia

ASJC Scopus subject areas

  • Biological Psychiatry


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