Basal forebrain neuronal inhibition enables rapid behavioral stopping

Jeffrey D. Mayse, Geoffrey M. Nelson, Irene Avila, Michela Gallagher, Shih Chieh Lin

Research output: Contribution to journalArticle

Abstract

Cognitive inhibitory control, the ability to rapidly suppress responses inappropriate for the context, is essential for flexible and adaptive behavior. Although most studies on inhibitory control have focused on the fronto-basal-ganglia circuit, we found that rapid behavioral stopping is enabled by neuronal inhibition in the basal forebrain (BF). In rats performing the stop signal task, putative noncholinergic BF neurons with phasic bursting responses to the go signal were nearly completely inhibited by the stop signal. The onset of BF neuronal inhibition was tightly coupled with and temporally preceded the latency to stop, the stop signal reaction time. Artificial inhibition of BF activity in the absence of the stop signal was sufficient to reproduce rapid behavioral stopping. These results reveal a previously unknown subcortical mechanism of rapid inhibitory control by the BF, which provides bidirectional control over the speed of response generation and inhibition.

Original languageEnglish (US)
Pages (from-to)1501-1508
Number of pages8
JournalNature Neuroscience
Volume18
Issue number10
DOIs
StatePublished - Oct 28 2015

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Aptitude
Psychological Adaptation
Basal Ganglia
Reaction Time
Basal Forebrain
Inhibition (Psychology)
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Basal forebrain neuronal inhibition enables rapid behavioral stopping. / Mayse, Jeffrey D.; Nelson, Geoffrey M.; Avila, Irene; Gallagher, Michela; Lin, Shih Chieh.

In: Nature Neuroscience, Vol. 18, No. 10, 28.10.2015, p. 1501-1508.

Research output: Contribution to journalArticle

Mayse, Jeffrey D. ; Nelson, Geoffrey M. ; Avila, Irene ; Gallagher, Michela ; Lin, Shih Chieh. / Basal forebrain neuronal inhibition enables rapid behavioral stopping. In: Nature Neuroscience. 2015 ; Vol. 18, No. 10. pp. 1501-1508.
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