Basal forebrain lesions facilitate adult host fiber ingrowth into neocortical transplants

C. F. Höhmann, F. F. Ebner

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of mature host thalamic neurons to innervate embryonic (E19) cortex when implanted into the cortex of adult hosts was compared in normal and basal forebrain lesioned mice. The ingrowth of mature horseradish peroxidase-labeled thalamic axons into the transplants is facilitated by prior basal forebrain lesions. We discuss the possible reasons for the lesion-induced enhancement of axonal ingrowth, including the possibility that the enhanced ingrowth of thalamic fiber systems may be related to the loss of cortical innervation by extrathalamic brainstem inputs, especially cholinergic afferent fibers. The results support the interpretation that extrathalamic inputs to cortex play a modulatory role in regulating the growth and connections of specific sensory fiber systems during brain responses to injury.

Original languageEnglish (US)
Pages (from-to)53-66
Number of pages14
JournalBrain research
Volume448
Issue number1
DOIs
StatePublished - May 10 1988

Keywords

  • Basal nucleus
  • Neocortex
  • Plasticity
  • Regeneration
  • Transplant

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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